ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1617199
Association between red cell distribution width to albumin ratio and clinical outcomes in elderly patients with sepsis: a cohort study
Provisionally accepted
- 1People's Liberation Army General Hospital, Beijing, China
- 2Department of Respiratory and Critical Care Medicine, The Second Medical Center, Chinese PLA general hospital, Bei jing, China
- 3Department of Cardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, Beijing Municipality, China
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Background: This study investigates the association between red cell distribution width to albumin ratio (RAR) and clinical outcomes in elderly sepsis patients. Methods: Using the eICU-CRD (2014)(2015), 5976 sepsis patients aged≥60 years were stratified into RAR quartiles at ICU admission: Q1 (≤5.28), Q2 (5.29-6.37), Q3 (6.38-7.87), and Q4 (7.88-15.0), with Q1 as the reference category. The primary outcome was 28-day hospital mortality, while secondary outcomes included ICU mortality, 90-day hospital mortality, and lengths of ICU and hospital stays. Multivariable regression analysis and spline curves from the generalized additive model were applied to assess the association between RAR and clinical outcomes. Kaplan-Meier survival analysis illustrated cumulative hospital mortality across RAR quartiles. Results: The 28-day hospital, ICU, and 90-day hospital mortality were 17.4%, 10.9%, 17.8%, respectively, with ICU and hospital stays of 2.9 (1.8-5.1) and 7.1 (4.6-11.7) days.Compared to Q1, Q4 exhibited significantly increased risks of 28-day hospital mortality (adjusted odds ratio [OR]: 2.95, 95% confidence interval [CI]: 2.28-3.80), ICU mortality (adjusted OR: 2.06, 95% CI: 1.52-2.78), 90-day hospital mortality (adjusted OR: 3.03, 95% CI: 2.35-3.90), and prolonged ICU (β: 0.89, 95% CI: 0.42, 1.36) and hospital stays (β: 1.64, 95% CI: 0.93, 2.36).Generalized additive model revealed linear relationship between RAR and mortality. Kaplan-Meier survival analysis demonstrated higher mortality with elevated RAR quartiles. Conclusion: Elevated baseline RAR is independently associated with adverse clinical outcomes in elderly sepsis patients, suggesting it may be a valuable tool for early risk stratification and personalized therapeutic interventions.
Keywords: Sepsis, Elderly, Red cell distribution width, albumin, Mortality
Received: 24 Apr 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 An, Fu, Chen, Xiong, Li, Lu, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhijian Zhang, Department of Respiratory and Critical Care Medicine, The Second Medical Center, Chinese PLA general hospital, Bei jing, China
Shan Li, People's Liberation Army General Hospital, Beijing, China
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