ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1618184
Association of oxidative balance score with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease
Provisionally accepted
- Heyuan People's Hospital, Heyuan, China
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Background: Cardio-renal-metabolic (CRM) conditions are increasingly recognized as a major public health challenge, with oxidative stress playing a pivotal role in poor prognosis. The oxidative balance score (OBS) is used to assess the body's oxidative stress status, but its link to all-cause and cardiovascular mortality in CRM patients remains unclear.We used data from participants (≥ 20 years old) in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The patients were divided into four groups based on OBS using the weighted quartiles method. The relationship between OBS and both all-cause and cardiovascular mortality in CRM patients was assessed using multivariable Cox regression and restricted cubic spline (RCS) models. The differences in cumulative survival between groups were examined using Kaplan-Meier analysis and log-rank tests. Sensitivity analysis and subgroup analysis were also performed.Results: During a median follow-up of 7.9 years, there were 3838(25.2%) and 1412(8.9%) patients who died from all-cause and cardiovascular mortality, respectively.After adjusting for potential confounders, elevated OBS level was negatively related to the risk of all-cause mortality (Q2, Q3, Q4: adjusted hazard ratio (aHR) [95 confidence interval (CI)%] =0.
Keywords: Cardio-renal-metabolic, Oxidative balance score, All-cause mortality, Cardiovascular mortality, NHANES
Received: 25 Apr 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Lin, Wang, Liu, Ye, Huang, Ou and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yangbin Ou, Heyuan People's Hospital, Heyuan, China
Jianhong Ma, Heyuan People's Hospital, Heyuan, China
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