ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1619371
Glucose and Lipid Metabolism in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnea: Sex DifferencesGlucose and lipid disorders in nondiabetic, non-obese Chinese patients with obstructive sleep apnea: sex differences
Provisionally accepted
- Renmin Hospital of Wuhan University, Wuhan, China
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Objective: Obstructive sleep apnea (OSA) is associated with glucose and lipid disturbances and insulin resistance. However, glucose and lipid disturbances and insulin resistance in OSA are often attributed to confounding obesity and/or diabetes. Studies on nondiabetic, nonobese OSA patients are very limited. Methods: This cross-sectional study retrospectively analyzed non-diabetic, non-obese adults who underwent a home sleep apnea testing and collected fasting blood samples before and after the sleep study to measure glucose and lipids. This study was designed as a cross-sectional study and therefore can only demonstrate associations between variables, but not causality.We retrospectively evaluated nondiabetic, nonobese adults undergoing home sleep apnea monitoring. Fasting blood was collected before or after sleep apnea monitoring for glucose and lipids. Conclusion: Our study supports the claim that there are sex gender differences in glucose and lipid metabolic disordersabnormalities in non-diabetic, non-obese OSA participants subjects: women mainly showed elevated fasting blood plasma glucose and TyG index, while men showed dyslipidemia with elevated triglycerides and decreased HDL-C. These findings highlight the need to consider gender sex differences when assessing OSA-related metabolic risks.
Keywords: obstructive sleep apnea, Glucose, Lipid, Triglyceride-glucose index, diabetes, Obesity, Sex
Received: 29 Apr 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Wang, Zhou, Yue, Wang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ke Hu, Renmin Hospital of Wuhan University, Wuhan, China
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