REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
This article is part of the Research TopicEmpowering Cancer Care: The Power of Nutrition and Fitness from Prevention to RecoveryView all 8 articles
The Impact of Diet and Gut Microbiota on Development, Treatment, and Prognosis in Prostate cancer
Provisionally accepted
- 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,, Beijing, China
- 2Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 3Institute of Clinical Medicine, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Prostate cancer (PCa) progression is driven by a complex interplay of factors, including genetics, lifestyle, and environmental influences. Diet and gut microbiota have emerged as pivotal cancer development and treatment response modulators. This review delves into the intricate relationship between dietary modifications and gut microbiota, and their combined impact on PCa progression. Diets abundant in plant-based foods, fiber, and prebiotics promote beneficial gut microbiota profiles that support anti-inflammatory and anti-carcinogenic processes. In contrast, the Western dietary pattern, characterized by high levels of saturated fats and processed foods, may lead to dysbiosis, fostering pro-inflammatory conditions and the production of metabolites that enhance tumorigenesis. The gut microbiota influences the behavior of PCa through immune modulation, metabolic by-products, and interactions with systemic therapies. Emerging evidence, primarily derived from preclinical models or studies in non-PCa contexts, suggests that diet and gut microbiota may influence the development and progression of PCa. However, further PCa-specific clinical research is needed to validate these associations. Future research should prioritize the development of precise dietary recommendations and microbiota-targeted therapies that can be seamlessly incorporated into clinical practice for more personalized and effective cancer care.
Keywords: PCA, Diet, Nutrients, Gut Microbiota, prognosis
Received: 01 May 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Liu, Yang, Song and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Song, sw-yy1990@163.com
Rui Hou, henrequelme@aliyun.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.