ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1623490
Vitamins improve the effect of heavy metal exposure in arthritis after hysterectomy
Provisionally accepted
- Changzhou Maternal and Child Health Care Hospital, Changzhou, China
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The interplay between gynaecological surgeries and arthritis pathogenesis remains poorly understood. This study offers new insights into potential health risks associated with post-hysterectomy.The cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, which cannot establish the causation. The effects of five serum heavy metal and nine vitamin intakes were evaluated.A total of 3121 participants with complete data from NHANES (2007~2018) were included in this study. The rates of arthritis in the participants with having undergone hysterectomy were significantly increased (58.25% vs 31.64%, p<0.001).Meanwhile, the levels of blood lead were significantly increased in the women having undergone gynaecological surgery (p<0.001) and the women with arthritis (p<0.001). After additionally adjusting, hysterectomy was still associated with an increased risk of arthritis (OR=3.33, p<0.0001). A nonlinear (L-shaped) relationship was observed in blood lead, mercury and cadmium (p for nonlinearity <.001). Blood lead was the highest WQS weigh among five heavy metals, with the highest contributions 0.72. Mediation analysis demonstrated that blood lead accounted for 6.02% of observed association between hysterectomy and arthritis (p<0.001). RCS curves were confirmed that there was a nonlinear (L-shaped) relationship between vitamin K, vitamin D and the risk of arthritis caused by hysterectomy (p<0.001).Hysterectomy is associated with increased risk of arthritis, with a focus on blood lead as a mediating factor and vitamin intake as a potential protective factor. It will contribute to the long-term health management after hysterectomy.
Keywords: Hysterectomy, Arthritis, heavy metal, Lead, vitamin
Received: 06 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 xu, wu, liu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bin Yu, Changzhou Maternal and Child Health Care Hospital, Changzhou, China
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