ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1623697
Association between triglyceride-glucose index and its obesity indicators with hypertension in postmenopausal women: A cross-sectional study
Provisionally accepted
- 1The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- 2Department of Neurology, Chinese PLA General Hospital, Beijing, China
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Background: This study explored the association between the triglyceride-glucose (TyG) index, combined with adiposity metrics, and hypertension prevalence in postmenopausal women.Methods: A cross-sectional study was conducted using data from 4,302 postmenopausal women in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Multivariable adjusted logistic regression models and restricted cubic splines (RCS) were implemented to assess the dose-response relationship. Receiver operating characteristic (ROC) curves were employed to compare the diagnostic performance of the TyG index, TyG-body mass (TyG-BMI), TyG-waist circumference (TyG-WC), and TyG-waist-to-height ratio (TyG-WHtR).Results: Multivariable-adjusted analyses demonstrated that the TyG index and its obesity indicators are significantly associated with hypertension risk. The RCS curve exhibited a non-linear relationship between TyG-WHtR and hypertension (P for non-linearity = 0.026), whereas other indices showed linear associations. ROC analysis confirmed the superior discriminative ability of TyG-WHtR for hypertension (AUC = 0.643, 95% CI 0.625–0.660).Conclusions: The TyG index and its combined obesity indicators, particularly TyG-WHtR, are strongly associated with hypertension risk in postmenopausal women. TyG-WHtR may serve as a valuable biomarker for targeted screening in this population.
Keywords: Metabolic biomarkers, Obesity, Hypertension, Postmenopausal Health, nutrition
Received: 06 May 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Zhang, Jiang, Ma and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bo Zhang, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Huanxian Liu, Department of Neurology, Chinese PLA General Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.