CLINICAL TRIAL article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1623699
This article is part of the Research TopicMaternal Metabolic Health: From Preconception to PostpartumView all 13 articles
Myo-inositol supplementation in Gestational Diabetes Mellitus: Is there any interference with Diet?
Provisionally accepted
Salma Hayder Ahmed
Ibrahim Ibrahim
Hala Abdullahi
Wided KhamlaouiChinnu George SamuelFariada Badri
Fatima AhmadGbemisola Okunoye
Annalisa Terranegra*- Sidra Medicine, Doha, Qatar
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Background/Objectives: Gestational Diabetes Mellitus (GDM) affects 31.6% of pregnant women in Qatar. Myo-inositol (MI) supplementation has been proposed to reduce GDM risk, but its interaction with diet and lifestyle remains unclear. This study assessed the effects of physical activity and diet on MI supplementation and GDM onset throughout pregnancy. Subjects/Methods: A randomized double-blind clinical trial was conducted at Sidra Medicine hospital, involving pregnant women assigned to either the MI (n=31) or placebo (PLA, n=33) arm.The Oral Glucose Tolerance Test (OGTT) was conducted between 24-28 weeks of gestation. Dietary intake was assessed using 24-hour dietary recall and Food Frequency Questionnaires (FFQ), and physical activity and lifestyle data were collected using questionnaires at each trimester. Nutrient analysis was performed using Nutritionist Pro, and dietary patterns were evaluated using the Healthy Eating Index (HEI) and Dietary Inflammatory Index (DII). Statistical analysis was conducted using Prism GraphPad (p ≤ 0.05). ISRCTN Registration number ISRCTN16448440.Results: Dietary adjustments during pregnancy included increased protein and fiber intake, reduced salt, and higher consumption of simple sugars. The MI group showed higher physical activity (walking time/week), lower weight gain, and increased fiber intake (beans and tubers) compared to PLA, which consumed more high-fat, high-sugar foods. Despite these differences, no major differences in GDM incidence were observed between groups.Conclusions: MI supplementation was associated with a healthier diet and higher physical activity.Findings suggest that an active lifestyle and balanced diet may enhance MI's efficacy in lowering GDM risk. Further research is needed to clarify this relationship.
Keywords: gestational diabetes mellitus, Pregnancy, myo-inositol, maternal diet, lifestyle
Received: 06 May 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Hayder Ahmed, Ibrahim, Abdullahi, Khamlaoui, Samuel, Badri, Ahmad, Okunoye and Terranegra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Annalisa Terranegra, Sidra Medicine, Doha, Qatar
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