EDITORIAL article
Front. Nutr.
Sec. Nutrigenomics
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1624517
This article is part of the Research TopicExtracellular Vesicles and miRNAs: Pioneers in Nutritional Science and Functional Food DevelopmentView all 5 articles
Editorial: Extracellular Vesicles and miRNAs: Pioneers in Nutritional Science and Functional Food Development
Provisionally accepted
Erika Cione1,2
Diego A. Bonilla3
Maria Cristina Caroleo4
Diana Marisol Abrego-Guandique4
Roberto Cannataro2*- 1University of Calabria, Rende, Italy
- 2University of Calabria, Cosenza, Italy
- 3Dynamical Business & Science Scoiety, Bogota, Colombia
- 4Magna Græcia University, Catanzaro, Italy
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https://mail.google.com/mail/u/0/?tab=rm&ogbl#search/frontiers/FMfcgzQZTzWmrhXpsSDZjL 16 FRDzrrGnnK 17The microRNAs (miRNAs) are small nucleotide sequences (20-25 bases) with epigenetic action, 18 in particular downregulation of protein synthesis; they have been seen for a long time as 19 subproducts without a defined biochemical and physiological function. They are found in almost 20 all biological fluids, in particular in the blood, they circulate mainly through extracellular vesicles 21 (EVs) often of small dimensions called exosomes (1 Our group shows how even the diet, specifically ketogenic (a nutritional program that allows a 56 maximum carbohydrate intake of 30g per day), affects miRNAs acting to regulate cognitive 57 function. However, miRNAs could be a handy tool to evaluate the positive action of the diet itself, 58 for example, in inflammatory status or in managing pathological conditions such as sarcopenia or 59 lipedema (8,9). 60We can conclude that the impact of EVs' microRNA cargo contained in foods on human health is 62 still inconclusive (10), because of the limitations of the molecular biology techniques used to 63 monitor them and/or the assessment of EVs' stability in the gastrointestinal tract. Future directions 64 should focus on EVs' stability using INFOGEST 2.0 and their content of conserved microRNA 65 cargo, the creation of an experimental model using organs-on-chip methodology to mimic the gut 66 environment, and the examination of the impact of the microbiome milieu on digesta EVs, 67 elucidating if microbes take EV-microRNA cargo, as is true for several polyphenols.All claims expressed in this article are solely those of the authors and do not necessarily represent 76 those of their affiliated organizations or those of the publisher, the editors, and the reviewers. Any 77 product that may be evaluated in this article, or claim that may be made by its manufacturer, is not 78 guaranteed or endorsed by the publisher. 79
Keywords: nutrition, MicroRNAs, extracellular vesicles, Milk, honey 14
Received: 07 May 2025; Accepted: 21 May 2025.
Copyright: © 2025 Cione, Bonilla, Caroleo, Abrego-Guandique and Cannataro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Roberto Cannataro, University of Calabria, Cosenza, Italy
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.