ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1624617
Correlation between body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis
Provisionally accepted
- 1Lanzhou University Second Hospital, Lanzhou, China
- 2lanzhou university, lanzhou city, China
- 3Lanzhou University Second Hospital, lanzhou city, China
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Background:Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, with abdominal fat, particularly visceral fat, closely associated with its onset and progression. While the lipid accumulation product (LAP) has been linked to COPD risk, it is not sufficient to fully reflect the level of visceral fat. In contrast, the body roundness index (BRI), a more accurate measure of abdominal fat distribution, has not been fully explored in relation to COPD. Methods:The study used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 for a cross-sectional analysis, including 24,873 participants aged over 40. Multivariate logistic regression models evaluated the relationship between BRI and COPD. Subsequently, sensitivity analysis, subgroup analysis, restricted cubic spline (RCS) modeling, and threshold effect evaluation were conducted. Results:Multivariate logistic regression analysis showed that for every 1-unit increase in BRI, the risk of COPD increased by 5.1% (95% CI: 1.022-1.080; p<0.001). Sensitivity analysis confirmed this conclusion (AUCBRL,0.78745, AUC LAP ,0.78675). In addition, BRI is significantly better than LAP(OR = 1.001, 95% CI: 1.000-1.001, P = 0.202) in predicting COPD. The restricted cubic spline (RCS) analysis showed a "U-shaped" relationship between BRI and COPD, and the threshold effect analysis determined the critical point of BRI to be 3.6583. Conclusion:This study demonstrates that the Body Roundness Index (BRI) is significantly associated with COPD risk, with a threshold effect observed at a BRI value of 3.6583. A 1-unit increase in BRI corresponds to a 5.1% higher COPD risk. BRI proves to be a more accurate indicator of abdominal fat distribution compared to traditional measures like the Lipid Accumulation Product (LAP), making it a useful tool for early COPD risk assessment and intervention.
Keywords: Chronic Obstructive Pulmonary Disease(COPD), Body roundness index(BRI), The National Health and Nutrition Examination Survey(NHANES), Abdominal Fat, Metabolism
Received: 07 May 2025; Accepted: 01 Aug 2025.
Copyright: © 2025 Li, Lin, Qin, LIU, Xiangji and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
YAN LIU, lanzhou university, lanzhou city, China
Dang Xiangji, Lanzhou University Second Hospital, lanzhou city, China
Cheng Wang, Lanzhou University Second Hospital, lanzhou city, China
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