ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Immunology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1625209
Associations between vitamin K and systemic immune and inflammation biomarkers: A population-based study from the NHANES (2007-2020) Authors
Provisionally accepted
- Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China
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With the aging of the population, finding effective interventions and treatments to delay chronic inflammation-related diseases is an urgent problem to be solved. Previous studies on animals have proposed that vitamin K can inhibit inflammation and may be a potential regulator of the immune inflammatory response. These findings suggested that increasing intake of vitamin K might also help reduce inflammation. This study included 36895 people from the National Health and Nutrition Examination Survey (2007–2020). Multivariate linear regression and restricted cubic spline analyses were conducted to explore the association between vitamin K intake and various immune inflammatory factors. Subgroup analyses were performed based on age, gender, ethnicity, BMI, hyperlipidemia, diabetes and hypertension. After multivariable adjustment, vitamin K intake is negatively correlated with SII, SIRI, SIIRI, NLR, white blood cell, neutrophil, and monocyte. When the level of vitamin K intake was less than 237.7 mcg/d, RAR showed a significant decreasing trend with the increase of vitamin K. When the vitamin K intake level was lower than 75.1 mcg/d, the basophil showed a downward trend with the increase of intake. However, when vitamin K levels exceed the inflection point, the above association no longer exists. These findings reveal that vitamin K intake is associated with reduced inflammatory status and improvements in immune inflammatory biomarkers. Vitamin K may modulate systemic immune and inflammatory markers, which may play a role in the development of chronic inflammation.
Keywords: Vitamin K, Systemic immune inflammatory index, systemic inflammatory response index, systemic immune-inflammation response index, neutrophil-tolymphocyte ratio
Received: 08 May 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Luo, Ye, Zhao, Zhou, Wu and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiuhua Ge, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China
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