REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1625987
This article is part of the Research TopicXenobiotics, Gut Microbiota, and Chronic DiseaseView all 11 articles
Dietary Microbes and Functional Dyspepsia: Modulating the Gut Microecology for Therapeutic Benefit
Provisionally accepted
- 1The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China
- 2Hubei University of Chinese Medicine,, Wuhan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The pathogenesis of functional dyspepsia (FD) is closely associated with intestinal microecological alterations. Dietary microorganisms, capable of modulating gut microecology and thereby influencing gastrointestinal function, are being explored as a promising therapeutic strategy against FD. However, the precise mechanisms underlying how dietary microbes exert beneficial effects through microecological modulation, along with therapeutic protocols, remain incompletely defined. This article systematically reviews the manifestations of intestinal microecological imbalance in FD and its proposed pathogenic mechanisms. We critically examine the role of dietary microorganisms in mitigating FD through microecological regulation, addressing their potential mechanisms of action and clinical impacts. Integrating advances in emerging diagnostic technologies, we further discuss feasible approaches and potential targets for personalized FD management. Current controversies and challenges within this research domain are analyzed, alongside perspectives for translating these findings into clinical practice. Collectively, this review aims to provide a comprehensive theoretical framework and inspire insights for both in-depth research and improved therapeutic strategies for FD.
Keywords: Gut Microbiota, Probiotics, Prebiotics, dietary microbiota, functional dyspepsia
Received: 09 May 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Huang, You, Liang and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fengxia Liang, Hubei University of Chinese Medicine,, Wuhan, China
Chaoyang Ma, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.