REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1626068
This article is part of the Research TopicDietary Influences on White and Brown Adipose Tissue: Mechanisms and Health ImplicationsView all 5 articles
The impact of dietary factors on the function of brown and beige adipose tissues -Implications on health and disease
Provisionally accepted
- State University of Campinas, Campinas, Brazil
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The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases. Currently, there is a great effort to identify or develop pharmacological agents that could promote adaptive thermogenesis. However, the greatest candidates, the 3-adrenergic receptor agonists, have proven troublesome as they promote unwanted cardiovascular effects. An important advance in the field of adaptive thermogenesis was made by the identification of nutrients or nutrient-derived substances that activate thermogenesis in brown and beige adipose tissue. The detailed characterization of the mechanisms by which nutrients activate thermogenesis could lead to changes in the nutritional guidelines for metabolic diseases.In addition, these studies could unveil new targets for the development of pharmacological strategies to treat metabolic and cardiovascular diseases. In this article, we review the data that led to the current understanding of the actions of nutrients or nutrient-derived substances as thermogenic agents.
Keywords: Thermogenesis, Mitochondria, Food, Calorie, Uncoupling protein
Received: 09 May 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Bombassaro, Batitucci, Reymond Simoes, Araujo and Velloso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bruna Bombassaro, State University of Campinas, Campinas, Brazil
Licio A Velloso, State University of Campinas, Campinas, Brazil
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