ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1628867
This article is part of the Research TopicNutrient Metabolism and Complications of Type 2 Diabetes MellitusView all 13 articles
Triglyceride glucose-body mass index is associated with diabetic kidney disease in type 2 diabetes mellitus patients without Non-alcoholic fatty liver disease
Provisionally accepted
- 1Ningbo Medical Center Lihuili Hospital, Ningbo, China
- 2The First Affiliated Hospital of USTC, Hefei, China
- 3Jinzhou Medical University, Jinzhou, China
- 4Jiangsu University Affiliated People’s Hospital, Zhenjiang, China
- 5The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
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Aim: The triglyceride-glucose body mass index (TyG-BMI) is correlated not only to the onset of diabetic kidney disease (DKD) associated with nutrition (including glucose and triglyceride) metabolism but also incorporates body mass index (BMI), potentially serving as an indicator of nonalcoholic fatty liver disease (NAFLD). But, the links between TyG-BMI and DKD in individuals with and without NAFLD remains further exploration. Therefore, this present research aims to investigate the relationship between TyG-BMI and DKD in these patient groups and to evaluate its diagnostic value for DKD.Methods: 425 individuals diagnosed with type 2 diabetes mellitus (T2DM) were categorized into the DKD group or the Control group. Clinical indicators were compared in these 2 groups, and the relationships between TyG-BMI and either the estimated glomerular filtration rate (eGFR) or the urinary albumin-to-creatinine ratio (UACR) were examined. Risk factors for DKD were examined, and the diagnostic value of TyG-BMI was assessed in patients without and with NAFLD.Results: Compared to 288 participants without DKD, 137 individuals with DKD exhibited higher TyG-BMI levels. In all individuals with T2DM, a higher TyG-BMI was recognized as a contributing factor to the development of DKD. Notably, this association was observed in patients without NAFLD, while no such link was established in those diagnosed with NAFLD. For T2DM patients lacking NAFLD, the TyG-BMI threshold of 49.2415 demonstrated a sensitivity of 91.3% and a specificity of 70.1%.Conclusions: Increased TyG-BMI values are associated with a higher risk of DKD and could act as potential indicators of DKD in individuals with T2DM.
Keywords: Triglyceride-glucose body mass index, Diabetic kidney disease, Diabetic complication, nonalcoholic fatty liver disease, type 2 diabetes mellitus
Received: 14 May 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Chu, Yao, Lu, Chang, Wang, Xu, Song, Feng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Zhang, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
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