REVIEW article
Front. Nutr.
Sec. Nutrition and Food Science Technology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1637316
Unlocking Iron: Nutritional Origins, Metabolic Pathways, and Systemic Significance
Provisionally accepted
Zoha Imtiaz Malik1Muhammad Umer Ghafoor2Syed Hassan Bin Usman Shah3Juweria Abid4Umar Farooq4
Abdul Momin Rizwan Ahmad5*- 1Health Services Academy, Islamabad, Pakistan
- 2Al Sadd Health Centre, Primary Health Corporation, Doha, Qatar
- 3University of New South Wales, Sydney, Australia
- 4National University of Medical Sciences, Rawalpindi, Pakistan
- 5University of York, York, United Kingdom
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Iron is a vital micronutrient, involved in numerous cellular functions including DNA synthesis, oxygen transport, energy generation, and immunity enhancement. It has unique redox properties that make it necessary for multiple metabolic reactions. However, the same property warrants its tight regulation as well. Despite its widely acknowledged role in biological sciences, iron deficiency remains one of the leading micronutrient deficiencies across the globe. Understanding iron's multifaceted roles, mechanisms of systemic regulation, and nutriture assessment, can better guide public health interventions aimed at restoring iron status in at-risk population groups. This review aims at providing a comprehensive analysis of iron's dietary sources, metabolic role, physiological functioning, absorption enhancers and inhibitors, and systemic regulation, such as hepcidin's role in iron homeostasis. It further evaluates commonly utilized iron assessment indicators including serum ferritin, transferrin saturation, soluble transferrin receptor, and hemoglobin their uses and limitations, particularly in the context of inflammation. Iron's metabolic roles are closely tied to its bioavailability and transportation within the body. Nutrient interactions, regulator pathway dysregulation, and dietary pathways, all significantly affect iron status. Available iron assessment indicators are valuable but research is required to interpret findings in inflammatory states. Advancement of integrated iron assessment strategies and metabolic roles can help address iron-related disorders more effectively.
Keywords: systemic regulation of iron, Assessment indicators, Iron absorption, iron homeostasis, Heme and non-heme iron
Received: 29 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Malik, Ghafoor, Shah, Abid, Farooq and Ahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Abdul Momin Rizwan Ahmad, University of York, York, United Kingdom
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