REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1646090
Efficacy of Collagen Peptide Supplementation on Bone and Muscle Health: A Meta-Analysis
Provisionally accepted
- Lanzhou University Second Hospital, Lanzhou, China
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Background: Collagen peptide supplements, especially when combined with vitamin D as well as calcium, are showing promise as a means of enhancing the condition of muscle and bone. This meta-analysis examined how collagen peptide intake affected muscular performance, bone turnover metrics, probability of fracture, and bone mineral density (BMD).Objective: The primary goal of this meta-analysis was to investigate the influence of collagen peptide treatment on musculoskeletal indices, bone turnover indicators, and bone mineral density (BMD). The interaction of collagen peptides with vitamin D and calcium was of special significance.Methods: Randomized trials evaluating collagen peptide intake, either independently or in combination with calcium and vitamin D, were systemtically reviewed and meta-analyzed. In order to synthesize effect sizes among trials, standardized mean differences (SMDs) using 95% confidence intervals were computed. The Cochran's Q analysis and the I2 measure were employed to determine variability.Results: Studies revealed that supplementing with collagen peptide significantly increased bone mineral density (BMD) in the femoral neck and spine. Although König et al. (2018) observed mild SMDs (0.58 for the spine and 0.46 for the femoral neck), other investigations like Hooshmand et al. (2013) andElam et al. (2015) found stronger impacts (SMDs >1.7). Nonetheless, there was a significant amount of variation in BMD results across trials (I 2 = 80.1%). Collagen had no noticeable variance (I 2 = 0%) and enhanced bone turnover indicators (SMD 0.40-0.58) and muscle performance (SMD 0.60 [0.05, 1.15]). When collagen was paired with the nutrients vitamin D and calcium, positive synergies were noticed (SMDs 0.40-0.56).Collagen peptide supplementation, particularly when synergized with calcium and vitamin D, is associated with continuous improvements in BMD, bone turnover markers, and muscle function. All these variables are important for fracture prevention. Owing to the information collagen peptides could be used as an adjunct therapy for managing osteoporosis.
Keywords: Collagen peptides, bone mineral density, prevention of fracture, Osteoporosis, Calcium, Vitamin D, Bone turnover markers, Muscle Strength
Received: 12 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Sun, Yang, Teng and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yayi Xia, Lanzhou University Second Hospital, Lanzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.