ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1646627
Triglyceride-glucose index, Renal Function, Sleep Duration, and Myocardial Infarction: A UK Biobank Cohort Study
Provisionally accepted
- 1Second Hospital of Anhui Medical University, Hefei, China
- 2The First Affiliated Hospital of USTC Hefei Ion Medical Center, Hefei, China
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Background: Myocardial infarction (MI) remains a leading cause of cardiovascular morbidity and mortality globally. Insulin resistance, renal function, and sleep duration are key risk factors, yet their combined impact on MI risk is underexplored. Methods: In this UK Biobank cohort study, 415,757 participants were included. Cox proportional hazards models estimated hazard ratios (HRs) for MI risk across quartiles of triglyceride-glucose (TyG) indices (TyG, TyG-BMI, TyG-WC, TyG-WHTR), stratified by eGFR and sleep duration categories. Mediation analyses evaluated interrelationships among TyG indices, eGFR, sleep duration, and MI. Results: Over follow-up, 13,484 participants developed MI. Higher TyG indices were associated with increased MI risk; TyG-WHTR showed the strongest effect (Q4 vs. Q1, HR: 1.90, 95% CI: 1.76–2.06). Reduced eGFR (<60) was linked to higher MI risk (HR: 1.71, 95% CI: 1.51–1.93), as were short (<7 h; HR: 1.20, 95% CI: 1.11–1.29) and long (>9 h; HR: 1.43, 95% CI: 1.22–1.68) sleep durations. TyG-MI associations were significant in participants with preserved renal function (eGFR ≥60) and short/normal sleep. Mediation analyses revealed that eGFR and sleep duration partially mediated the associations between TyG indices and MI risk, and vice versa, indicating complex interrelations. Conclusion: TyG-related indices are valuable predictors of MI risk, particularly in individuals with preserved renal function and typical sleep duration. The interplay among insulin resistance, renal function, and sleep patterns underscores the importance of integrated metabolic and lifestyle factors in cardiovascular risk stratification.
Keywords: Triglyceride-glucose index, Myocardial Infarction, Renal function, sleep duration, Insulin Resistance
Received: 13 Jun 2025; Accepted: 15 Aug 2025.
Copyright: © 2025 Liu, Wang, Pan, Zhang, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zeyan Liu, Second Hospital of Anhui Medical University, Hefei, China
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