ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1647671
This article is part of the Research TopicDietary Modulation of Gut Microbiota-X axisView all 15 articles
Bifidobacterium adolescentis CCFM1447 effectively alleviates osteoporosis by enriching intestinal flora capable of vitamin D conversion
Provisionally accepted
Xihua Yu1,2
Gao Tian3,4
Yi Wang1,2Liuruolan Li1,2
Liming Huang3,4Yurong Zhao3,4Ling Feng3,4Yuhao Zhao3,4
Wenwei Lu3,4,5Shourong Lu6*
Hongchao Wang3,4*- 1Sinopharm Xingsha Pharmaceutical Xiamen Co Ltd, Xiamen, China
- 2Xiamen Key Laboratory of Maternal and Infant Health and Nutrition Products, Xiamen, China
- 3Jiangnan University School of Food Science and Technology, Wuxi, China
- 4State Key Laboratory of Food Science & Resources, Wuxi, China
- 5National Engineering Research Center for Functional Food, Wuxi, China
- 6The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, China
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Elderly individuals exhibit heightened susceptibility to osteoporosis, largely attributable to agerelated declines in skin, liver, and kidney function. While vitamin D (VD) supplementation is common, its efficacy is often limited, necessitating reliance on pharmaceutical interventions. Research indicates that the intestinal flora significantly influences intestinal VD metabolism, with probiotic supplementation demonstrably impacting circulating VD levels. Consequently, we employed an fecal fermentation model to screen bacterial strains, identifying Bifidobacterium adolescentis CCFM1447 for its capacity to elevate VD metabolite levels within fermented supernatants. Intervention with CCFM1447 in osteoporotic mice resulted in significantly elevated serum concentrations of 1,25-dihydroxyvitamin D. Furthermore, this intervention improved bone microarchitecture, evidenced by increased trabecular number and bone volume fraction. In addition, the intestinal flora of the osteoporotic mice was disturbed. CCFM1447 intervention increased the relative abundance of beneficial bacteria such as Adlercreutzia equolifaciens, Akkermansia muciniphila and Pediococcus acidilactici. And it is enriched with a part of strains that have the ability to transform VD such as Enterococcus faecalis and Pediococcus acidilactici. The above results suggest that B. adolescentis CCFM1447 may alleviate retinoic acid-induced osteoporosis symptoms by modulating the intestinal flora and increasing the level of active vitamin D.
Keywords: Osteoporosis, intestinal flora, Vitamin D, active vitamins, Probiotics
Received: 16 Jun 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Yu, Tian, Wang, Li, Huang, Zhao, Feng, Zhao, Lu, Lu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shourong Lu, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, China
Hongchao Wang, Jiangnan University School of Food Science and Technology, Wuxi, China
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