ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1648394
Ten Weeks of 100% Orange Juice Consumption Had a Marginal Effect on Women’s Skin Health Compared to a Low-Flavanone Orange-Flavored Control Beverage: A Pilot Randomized Trial
Provisionally accepted
- University of Florida, Gainesville, United States
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Human skin health deteriorates after age 40, particularly due to ultraviolet (UV) radiation, a major extrinsic factor contributing to photoaging. This study investigated whether daily consumption of 100% orange juice could reduce UVB-induced erythema, improve skin health, and lower biomarkers of oxidative stress and inflammation. A randomized, single-blinded, crossover trial was conducted in 24 healthy women aged 40–65. Participants consumed 12 oz of 100% orange juice or an orange-flavored control beverage daily for 10 weeks, followed by a 28-day washout before switching beverages for another 10 weeks. Skin assessments and blood sample collection were conducted at baseline, week 5, and week 10. Orange juice offers significantly higher daily flavanone content (81.46 mg/day) than the control beverage (29.60 mg/day). Ten weeks of orange juice consumption significantly reduced forearm wrinkles and showed a trend toward reduced skin roughness. However, no significant improvements were observed in UVB-induced erythema and other skin health parameters, including transepidermal water loss, skin hydration, or elasticity. Furthermore, blood levels of matrix metalloproteinase-9, advanced glycation end products, superoxide dismutase, glutathione peroxidase, IL-6, TNF-α, and high-sensitivity C-reactive protein remained unchanged. In conclusion, daily consumption of orange juice for ten weeks had a marginal effect on skin health.
Keywords: ORANGE JUICE, UVB-induced erythema, Skin health, Oxidative Stress, Inflammation
Received: 17 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Fu and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liwei Gu, University of Florida, Gainesville, United States
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