ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1651750
This article is part of the Research TopicInnovative Approaches to Nutrition Counseling in Pediatric Dietetics - Guidelines, Practices, and Future DirectionsView all 10 articles
Predictive value of novel nutritional inflammation indexes in IVIG-unresponsive Kawasaki disease: a retrospective study
Provisionally accepted
- Mianyang Central Hospital, Mianyang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: This retrospective study aimed to investigate the predictive value of novel albumin-associated nutritional inflammation markers, including the C-reactive protein-albumin-lymphocyte (CALLY) index, C-reactive protein to albumin ratio (CAR), neutrophil-to-albumin ratio (NAR), neutrophil percentage‑to‑albumin ratio (NPAR) and prognostic nutritional index (PNI), for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) patients. Methods: We conducted a retrospective analysis of clinical data from pediatric patients diagnosed with KD and admitted to our hospital between January 2012 and November 2023. Data were analyzed using univariate analysis, binary logistic regression analysis, and receiver operating curve (ROC) analysis. Results: The study included 716 children with KD, and 78 of them (10.9%) were diagnosed with IVIG-resistant KD. CAR, NAR and NPAR were positively correlated with IVIG resistance, while the CALLY index and PNI showed negative correlations. The area under the ROC curve (AUC) values of the CALLY index, CAR, NAR, NPAR and PNI were 0.725, 0.700, 0.580, 0.717 and 0.712. Conclusion: Our findings suggest that these novel nutritional inflammation indexes could be useful tools for predicting IVIG resistance in KD patients, potentially guiding timely intensified therapy. Compared to NAR, the CALLY index, CAR, NPAR, and PNI demonstrate stronger predictive performance for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease and may hold greater potential for clinical application.
Keywords: kawasaki disease, C-reactive protein-albumin-lymphocyte index, C-reactive protein to albumin ratio, neutrophil-to-albumin ratio, neutrophilpercentage‑to‑albuminratio, prognosticnutritionalindex, intravenousimmunoglobulin resistance
Received: 22 Jun 2025; Accepted: 11 Sep 2025.
Copyright: © 2025 Yi, Xue, Chen, Guo, Zhou, Hu and She. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yu Hu, huyu0443@126.com
Xiang She, xiangshe6784@126.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.