ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1657646
Comparative study on the predictive value of TyG, TyG-BMI, and TG/HDL-C for progression-free survival in patients with locally advanced nasopharyngeal carcinoma
Provisionally accepted
- 1Guangxi Medical University Cancer Hospital, Nanning, China
- 2Guangxi University, Nanning, China
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Background: This study aims to explore the relationship between the triglyceride glucose (TyG), triglyceride glucose body mass index (TyG-BMI), and triglyceride-density lipoprotein cholesterol ratio (TG/HDL-C) of locally advanced nasopharyngeal carcinoma (LA-NPC) and progression-free survival (PFS) to investigate their value as prognostic indicators for patients. Methods: This research performed a retrospective analysis of data pertaining to patients with LA-NPC from the Guangxi Medical University Cancer Hospital. Categorized into a progression group and a control group according to disease control status. The correlation of three indicators with PFS was established utilizing the Cox proportional hazards model, Kaplan-Meier (K-M) analysis, and restricted cubic spline (RCS) analysis. Three models were developed based on the three indicators, and assessed the predictive ability of the models. Results: TyG, TyG-BMI, and TG/HDL-C are independent predictors of PFS in LA-NPC patients, and all exhibit a nonlinear relationship. Patients in the high TyG, TyG-BMI, and TG/HDL-C groups have significantly lower PFS compared to those in the low groups, and this effect persists after adjusting for confounding factors. Multivariate analysis confirms that LDH and EBV_DNA are also independent prognostic factors for PFS. The models that utilize these indicators outperform traditional TNM staging, with TyG-based model demonstrating the strongest predictive ability for PFS. Conclusion: TyG, TyG-BMI, and TG/HDL-C are potential prognostic biomarkers for the evaluation of PFS in individuals diagnosed with LA-NPC. Our research underscores the potential of these three indices are utilized to enhance prognostic assessment and customize treatment strategies in the management of LA-NPC.
Keywords: nasopharyngeal carcinoma, locally advanced, TyG, TyG-BMI, TG/HDL-C
Received: 01 Jul 2025; Accepted: 03 Sep 2025.
Copyright: © 2025 ZHEHAO, Liang, Chen, Huang and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Song Qu, Guangxi Medical University Cancer Hospital, Nanning, China
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