ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1664640
This article is part of the Research TopicNutritional Status and Nutritional Support in Hospitalized PatientsView all articles
The Association Between Fluid Balance Trajectories and Prognosis in ICU Patients with Cardiac Arrest: A Group-Based Trajectory Model Analysis
Provisionally accepted
- Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
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The impact of dynamic fluid balance (FB) changes on the prognosis of ICU patients with cardiac arrest (CA) remains unclear. This study aims to explore the association between FB trajectories and the prognosis of such patients. Methods: Data were sourced from CA patients in the MIMIC-IV database. A Group-Based Trajectory Model (GBTM) was used to identify patient subgroups with similar FB trajectories. Kaplan-Meier survival curves and Cox regression models were applied to analyze the association between FB trajectories and survival outcomes in CA patients. Subgroup and sensitivity analyses were conducted to further validate the robustness of the results. Results: A total of 876 CA patients were included. Four distinct FB trajectory patterns were identified: Trajectory 1 (rapid transition to negative balance), Trajectory 2 (stable balance), Trajectory 3 (positive balance gradually decreasing), and Trajectory 4 (decreasing at a high level). Kaplan-Meier survival analysis showed that the survival rate in Trajectory 1 was significantly higher than in the other trajectory groups, with the fluid overload group exhibiting a notably higher mortality risk than the non-overload group. Cox proportional hazards analysis indicated that, after adjusting for various covariates, the survival rate in Trajectory 1 remained significantly higher than in other trajectory groups (Reference:
Keywords: Cardiac arrest, Fluid balance, group-based trajectory model, MIMIC-IV database, prognosis
Received: 12 Jul 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Zhang, Lin and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qitian Zhang, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China
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