ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1666754
This article is part of the Research TopicIntegrating Nutrition in Cancer Therapy: Approaches to Improve Patient Outcomes and SurvivalView all 5 articles
MORPHOFUNCTIONAL PARAMETERS AS PREDICTORS OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION OUTCOMES
Provisionally accepted- Health Research Institute Foundation Jimenez Diaz (IIS-FJD), Madrid, Spain
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Introduction: There is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional assessment is not usually performed before the procedure. Malnutrition is related to lower survival in cancer patients. Our aim is to identify both risk and protective factors for such complications to refine management and improve outcomes. Methods: We have implemented the program ‘RHeNutrir’, which involves a systematic malnutrition and sarcopenia screening, as well as a complete nutritional and functional assessment of transplant candidates. We examined the predictive value of different morphofunctional, clinical and analytical parameters in the context of autologous transplantation. Results: Anemia, respiratory diseases and diabetes mellitus are associated with many complications and should be optimized before transplant. Elevated C-reactive protein and greater fat mass, as inflammatory biomarkers, are related to fever, longer hospitalization, and even death. Bacteremia and intensive care unit admission are associated with higher mortality. However, better muscle strength and greater lean mass on admission are associated with a lower incidence of these complications and higher albumin levels at discharge are related to a lower risk of early readmission. Conclusion: Body composition and muscular function studies should be performed in patients who are candidates for this procedure, and prehabilitation and nutritional intervention protocols should be designed to improve outcomes.
Keywords: Morphofunctional, Hand-held dynamometry, bioelectrical impedance analysis, Malnutrition, Sarcopenia, Autologous stem cell transplantation
Received: 15 Jul 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Cornago Navascués, Dassen Llorca, Calderón Sánchez, Mahíllo Fernández, Pardo Gambarte, López Lorenzo, Hormigo Sánchez, Caballero Hernáez, Domingo-González, Capellán García, Iturrate Basarán, Pérez de Camino Gaisse, Sánchez Fernández, Teixeira Taborda, del Pecho Fombellida, Llamas Sillero and Solán Blanco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Javier Cornago Navascués, Health Research Institute Foundation Jimenez Diaz (IIS-FJD), Madrid, Spain
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