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ORIGINAL RESEARCH article

Front. Nutr.

Sec. Nutritional Epidemiology

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1666754

This article is part of the Research TopicIntegrating Nutrition in Cancer Therapy: Approaches to Improve Patient Outcomes and SurvivalView all 5 articles

MORPHOFUNCTIONAL PARAMETERS AS PREDICTORS OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION OUTCOMES

Provisionally accepted
Javier  Cornago NavascuésJavier Cornago Navascués*Carolina  Dassen LlorcaCarolina Dassen LlorcaCristina  Calderón SánchezCristina Calderón SánchezIgnacio  Mahíllo FernándezIgnacio Mahíllo FernándezLaura  Pardo GambarteLaura Pardo GambarteJosé Luis  López LorenzoJosé Luis López LorenzoAna Isabel  Hormigo SánchezAna Isabel Hormigo SánchezJuan Carlos  Caballero HernáezJuan Carlos Caballero HernáezAmalia  Domingo-GonzálezAmalia Domingo-GonzálezRaquel  Capellán GarcíaRaquel Capellán GarcíaIsabel  Iturrate BasaránIsabel Iturrate BasaránBegoña  Pérez de Camino GaisseBegoña Pérez de Camino GaisseMaría Soledad  Sánchez FernándezMaría Soledad Sánchez FernándezÁstrid  Teixeira TabordaÁstrid Teixeira TabordaMarta  del Pecho FombellidaMarta del Pecho FombellidaPilar  Llamas SilleroPilar Llamas SilleroLaura  Solán BlancoLaura Solán Blanco
  • Health Research Institute Foundation Jimenez Diaz (IIS-FJD), Madrid, Spain

The final, formatted version of the article will be published soon.

Introduction: There is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional assessment is not usually performed before the procedure. Malnutrition is related to lower survival in cancer patients. Our aim is to identify both risk and protective factors for such complications to refine management and improve outcomes. Methods: We have implemented the program ‘RHeNutrir’, which involves a systematic malnutrition and sarcopenia screening, as well as a complete nutritional and functional assessment of transplant candidates. We examined the predictive value of different morphofunctional, clinical and analytical parameters in the context of autologous transplantation. Results: Anemia, respiratory diseases and diabetes mellitus are associated with many complications and should be optimized before transplant. Elevated C-reactive protein and greater fat mass, as inflammatory biomarkers, are related to fever, longer hospitalization, and even death. Bacteremia and intensive care unit admission are associated with higher mortality. However, better muscle strength and greater lean mass on admission are associated with a lower incidence of these complications and higher albumin levels at discharge are related to a lower risk of early readmission. Conclusion: Body composition and muscular function studies should be performed in patients who are candidates for this procedure, and prehabilitation and nutritional intervention protocols should be designed to improve outcomes.

Keywords: Morphofunctional, Hand-held dynamometry, bioelectrical impedance analysis, Malnutrition, Sarcopenia, Autologous stem cell transplantation

Received: 15 Jul 2025; Accepted: 04 Sep 2025.

Copyright: © 2025 Cornago Navascués, Dassen Llorca, Calderón Sánchez, Mahíllo Fernández, Pardo Gambarte, López Lorenzo, Hormigo Sánchez, Caballero Hernáez, Domingo-González, Capellán García, Iturrate Basarán, Pérez de Camino Gaisse, Sánchez Fernández, Teixeira Taborda, del Pecho Fombellida, Llamas Sillero and Solán Blanco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Javier Cornago Navascués, Health Research Institute Foundation Jimenez Diaz (IIS-FJD), Madrid, Spain

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