REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1667377
This article is part of the Research TopicLong-term Sequelae of Childhood ObesityView all articles
Efficacy of non-pharmacological treatments in pediatric MASLD: a review of the literature
Provisionally accepted
- 1Bambino Gesù Children's Hospital (IRCCS), Rome, Italy
- 2Universita degli Studi di Roma Unitelma Sapienza, Roma, Italy
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Metabolic-associated fatty liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), comprises a spectrum of liver disorders characterized by excessive accumulation of triglycerides in hepatocytes. There are multiple treatment strategies proposed for pediatric MASLD, with lifestyle modifications and a balanced dietary regimen – particularly the Mediterranean diet in combination with weight loss, when needed – currently representing the cornerstone of clinical management. Behavioral psychological interventions are gaining increasing importance particularly in addressing comorbid eating disorders and supporting long-term adherence to therapeutic regimens. In addition, in daily clinical practice, the use of food supplements with antioxidant and hepatocyte anti-inflammatory effects is indicated in more advanced stages of steatosis, with the aim of limiting disease progression towards high-grade fibrosis and/or cirrhosis. This review aims to summarize current behavioral and nutritional therapeutic approaches for the management of pediatric MASLD.
Keywords: MASLD, pediatric, Non-pharmacologic therapy, physical activity, mediterranean diet
Received: 16 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Mosca, pietrobattista, alisi and vania. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Antonella Mosca, antonella.mosca@opbg.net
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