ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Low Iron Status and Cognitive Impairment in Northern China Community-Dwelling Older Adults: A Cross-Sectional Study
Provisionally accepted
- 1Department of Epidemiology, Shanxi Medical University, Taiyuan, China
- 2Department of General Practice, Shanxi Medical University, Taiyuan, China
- 3Department of Mathematics and Statistics, Pomona College, Claremont, United States
- 4Beiying Community Health Service Center, Taiyuan , Shanxi, China
- 5Department of Geriatric Medicine, Shanxi Bethune Hospital, Taiyuan, China
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Background: The association between serum iron concentration and cognitive ageing remains inconsistent, particularly in rural Chinese populations where both iron deficiency and excess may coexist. Methods: In this cross-sectional analysis of 737 community-dwelling adults aged ≥60 years from rural Taiyuan, China, cognitive impairment was assessed with the Chinese-language Mini-Mental State Examination (MMSE) using education-specific cut-offs. Serum iron was quantified by inductively coupled plasma-mass spectrometry and categorised into tertiles (low, medium, high). Multivariable logistic regression models adjusted for sociodemographic, lifestyle and clinical covariates examined independent and joint associations; restricted cubic splines (RCS) evaluated dose-response patterns. Results: After comprehensive adjustment, serum iron demonstrated a non-linear relationship with cognitive impairment risk. Relative to the lowest tertile, medium (OR = 0.61, 95% CI: 0.39–0.95) and high (OR = 0.59, 95% CI: 0.37–0.93) serum iron concentrations were associated with reduced odds of cognitive impairment. Spline analysis suggested a U-shaped relationship: risk decreased with rising serum iron up to a nadir and then trended upward; however, the departure from linearity was not statistically significant (P-nonlinear = 0.194). Conclusion: Both low and high serum iron levels are linked to poorer cognitive performance in this rural cohort, supporting the need to maintain iron within an optimal range for healthy cognitive ageing.
Keywords: Cognitive Function, elderly population, Risk factors, Serum, Iron
Received: 25 Jul 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Xin, Liu, Li, Feng, Hao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Wang, wang_leicn@163.com
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