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ORIGINAL RESEARCH article

Front. Nutr.

Sec. Clinical Nutrition

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1674853

Nutritional status and prevalence of anemia in patients with Crohn's disease after surgery: a multicenter cross-sectional study in China

Provisionally accepted
Yu  ShenYu Shen1Huaying  LiuHuaying Liu2Jing  LiuJing Liu3Changling  TangChangling Tang4Zhijian  LiuZhijian Liu5Xujie  DaiXujie Dai6Wei  LiuWei Liu3Qian  CaoQian Cao7Xiaolong  GeXiaolong Ge3,7*Wei  ZhouWei Zhou3
  • 1Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
  • 2Department of Medicine, Guangxi Health Science College, Guangxi, China, Guangxi, China
  • 3Department of surgery, Sir run run shaw hospital, Zhejiang University, Hangzhou, China
  • 4Deqing People`s Hospital, Huzhou University, Huzhou, Zhejiang, China, Hangzhou, China
  • 5Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China
  • 6Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Nanjing, China
  • 7Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China

The final, formatted version of the article will be published soon.

Background: Malnutrition and anemia are major concerns that significantly impact quality of life and disease activity in patients with Crohn's disease (CD) following surgical resection. However, comprehensive data on nutritional status and anemia in post-surgical CD patients remain limited. This study aims to evaluate the prevalence of malnutrition and anemia in a multi-center cohort of CD patients after surgery. Methods: In this cross-sectional study, patients with CD who underwent bowel resection across 20 provinces in China were evaluated for nutritional status and anemia. Biochemical parameters were collected and analyzed to explore their associations with nutritional status and anemia. Results: A total of 160 patients, with a mean age of 37.6 years and 63.8% male, were enrolled. Malnutrition was observed in 47.5% of patients, with 56.3% at risk of malnutrition post-surgery. Malnourished patients exhibited lower nutritional indicators and more severe disease activity. Anemia was detected in 60.6% of patients, with 79.4% having mild anemia and 20.6% moderate anemia. Patients with post-surgical anemia showed elevated inflammatory markers and increased disease activity. Both malnutrition and anemia were significantly associated with reduced quality of life (p<0.05). Conclusion: Malnutrition and anemia were highly prevalent and negatively impacted patients with CD following surgery. Screening and early preventive management of malnutrition and anemia were critical components of postoperative care in CD.

Keywords: Crohn's disease, Surgery, Malnutrition, Anemia, a multicenter cross-sectional study

Received: 06 Aug 2025; Accepted: 29 Sep 2025.

Copyright: © 2025 Shen, Liu, Liu, Tang, Liu, Dai, Liu, Cao, Ge and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Xiaolong Ge, gxlmed@zju.edu.cn

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