REVIEW article
Front. Nutr.
Sec. Food Chemistry
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1677196
Recent Advances in the Biosynthetic Mechanisms, Regulation, and Detoxification Strategies of Deoxynivalenol (DON) in Fusarium graminearum
Provisionally accepted
- 1Guangzhou Panyu Polytechnic, Guangzhou, China
- 2Jiangxi Agricultural University, Nanchang, China
- 3Yunnan Agricultural University, Kunming, China
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Fusarium graminearum, the major causal agent of Fusarium head blight (FHB), produces the trichothecene mycotoxin deoxynivalenol (DON), which threatens food and feed safety worldwide.is the primary fungal pathogen causing Fusarium Head Blight (FHB) in wheat, with its mycotoxin, deoxynivalenol (DON), posing a major threat to global food security and safety. This review provides a comprehensive overview of recent advances in the biosynthetic mechanisms and regulatory pathways involved in DON production, including key genes, transcription factors, and signaling cascades. This review synthesizes recent advances in DON biosynthesis, emphasizing the TRI gene cluster and its pathway enzymes, transcriptional regulators, and signaling cascades. In parallel, it provides a comprehensive analysis of the molecular mechanisms involved in regulating DON biosynthesis, with a focusing on the TRI cluster. In Aadditionally, current progress in detoxification strategies is summarized, covering physical, chemical, and biological methods aimed at mitigating DON contamination in food and feed. Thise review further explores the endogenous environmental factors influencing DON synthesis and offering insights tofor the development of integrated control strategies against DON contamination. By integrating the current findings, this reviewwork aims to support the development of effective strategies, and for controlling F. graminearum and mitigateing FHB.
Keywords: Fusarium head blight, Deoxynivalenol, Biosynthetic mechanisms, regulation, Detoxification Strategies and control
Received: 31 Jul 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 He, Lei, Yan, Gu and SUN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaolong Gu, xuewu24588@126.com
Chao SUN, jackssunc@jxau.edu.cn
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