REVIEW article
Front. Nutr.
Sec. Nutrition Methodology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1681162
Healthy dietary patterns and ovarian cancer risk and survival: a systematic review and meta-analysis
Provisionally accepted
- Zhuji sixth people’s Hospital, Zhuji, China
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Background: Studies investigating the associations between healthy dietary pattern and risk and survival of ovarian cancer have been limited and inconsistent. Therefore, we carried out this comprehensive systematic review and meta-analysis to analyze the available literature on the associations between healthy dietary patterns and risk and survival of ovarian cancer. Methods: PubMed, Web of Science, Scopus and China National Knowledge Infrastructure (CNKI) were comprehensively searched for the relevant articles published from databases inception to October 2024. According to heterogeneity, the pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated for the highest versus the lowest categories of healthy dietary patterns in relation to ovarian cancer risk and survival, using the random-effects or fixed-effects meta-analyses. Results: Sixteen studies (twelve cohort and four case-control studies) with 615,203 participants, 5,452 ovarian cancer cases and 3,028 ovarian cancer deaths were included in the final analysis. Combining fifteen effect sizes from eight studies, we found the evidence of a reduced risk of ovarian cancer in the highest compared with the lowest categories of healthy dietary patterns (RR=0.91; 95%CI: 0..85-0.98, P=0.013). The pooled analyses also revealed that healthy dietary patterns was associated with improved ovarian cancer survival (RR=0.85; 95%CI:0.0.76-0.95, P=0.004), with significant heterogeneity (I2=54.3%, P=0.004). Moreover, per SD increment in healthy dietary score was related to a 14% reduced risk of ovarian cancer mortality (RR=0.86; 95%CI:0.81-0.91, P<0.001). Conclusion: Our findings demonstrated that high adherence to the healthy dietary patterns was associated with a reduced risk and improved survival of ovarian cancer.
Keywords: Dietary patterns, ovarian cancer, Survival, Systematic review, Meta-analysis
Received: 07 Aug 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Xu, Chen and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yiyi Xu, m13626751440@163.com
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