Impact of the Mediterranean Diet on stroke incidence and cognitive impairment in CADASIL and CAA patients: the DIETETICA study

Camilla Strazzabosco¹Benedetta Storti^1*Giulia Marinoni¹Carolina De Toma¹Isabella Canavero¹Nicola Rifino¹Giorgio B Boncoraglio¹Esteban Zacarias¹Alessandro Francia^1,2Giuliana Pollaci¹Tatiana Carrozzini¹ANTONELLA POTENZA¹Gemma Gorla¹Ramona De Amicis^3,4LAURA GATTI¹Anna Bersano¹

• ¹IRCCS Carlo Besta Neurological Institute Foundation, Milan, Italy
• ²Department of Biomedical and Clinical Sciences, University of Milan, Italy, Milan, Italy
• ³International Center for the Assessment of Nutritional Status and the Development of Dietary Intervention Strategies (ICANS-DIS), University of Milan, Italy, Milan, Italy
• ⁴I.R.C.C.S. Istituto Auxologico Italiano, Obesity Unit and Laboratory of Nutrition and Obesity Research, Milan, Italy., Milan, Italy

Cerebral small vessel disease (cSVD), including Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Cerebral Amyloid Angiopathy (CAA), is a major cause of non-sporadic stroke and cognitive impairment. Despite the recognized benefits of the Mediterranean Diet (MD) on cardiovascular and neurodegenerative diseases, its role in cSVD has not been yet investigated. The DIETETICA study ("Effect of Mediterranean Diet on stroke incidence and cognitive impairment in patients with CADASIL and CAA") aims to explore the association between MD adherence, stroke incidence and cognitive impairment in patients affected by CADASIL and CAA. During observational phase, 22 participants were recruited: 9 with CADASIL and 13 with CAA. 68.18% were male and 31.82% were female. According to the response obtained through a validated 14-item questionnaire, 63.63% of the total cohort had moderate adherence to MD, 27.27% had low adherence, and 9.09% had high adherence. Differences in body composition, in terms of fat mass (FM) and fat-free mass (FFM), were observed between the two patient cohorts. Overall, the preliminary observations regarding dietary daily intake were characterized by inadequate of nutrients which are known to have neurovascular benefits, such as polyunsaturated fatty acids (PUFAs), calcium, potassium and vitamin D, for both CADASIL and CAA patients. The present study will pave the way to the evaluation of the effects of MD pattern on cSVD, in order to provide evidence-based dietary recommendations aimed at reducing stroke incidence and cognitive impairment.