REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
This article is part of the Research TopicDietary Antioxidants and their Impact on Oxidative Stress and Cancer PreventionView all articles
Dietary Polyphenols as Modulators of Cell Signaling and Inflammation in Colorectal Carcinogenesis
Provisionally accepted
- 1Faculty of Health and Life Sciences, Management and Science University, Shah Alam, Malaysia
- 2Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia, Serdang, Malaysia
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Colorectal cancer is the second leading cause of cancer mortality worldwide. Although current chemopreventive drugs can suppress the proliferation of cancer cells, their use is often limited by adverse side effects, including toxicity, development of resistance, and lack of selectivity. The main side effects associated with continuous infusion of 5‑fluorouracil (5-FU) such as mucositis, vomiting, nausea, and diarrhea. Dietary factors play a critical role in colorectal cancer management and have gained attention as alternative strategies for cancer prevention. Evidence from preclinical and human studies suggests that polyphenols exert anti-colon cancer activity. However, the mechanisms underlying these effects remain poorly understood. This review highlighted the potential of polyphenol-rich foods in the prevention of colorectal cancer, particularly on molecular aspects that may provide a plausible means for the prevention of colorectal cancer. Overall, elucidating the role of polyphenols in redox regulation of inflammation may offer useful strategies for intervention and contribute to colorectal cancer prevention.
Keywords: antioxidant, colorectal cancer, Flavonoid, Inflammation, Oxidativestress, polyphenol
Received: 24 Aug 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Tan, Zulkifli and MOHD ESA. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bee Ling Tan, tbeeling@msu.edu.my
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