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ORIGINAL RESEARCH article

Front. Nutr.

Sec. Nutrition and Metabolism

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1691625

Association between CT-derived skeletal muscle and fat indices and fracture healing following operative treatment for intertrochanteric fractures: a multicenter retrospective study

Provisionally accepted
  • 1Wenzhou Medical College Affiliated Yueqing Hospital, Yueqing, China
  • 2The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

Background: Intertrochanteric fractures account for nearly 50% of hip fractures in elderly patients and are primarily treated with internal fixation. Considerable variability in postoperative healing persists, with delayed union or nonunion prolonging immobilization and increasing complications and healthcare costs. Accurate, objective assessment of healing is essential, and the Radiographic Union Score for Hip (RUSH) offers a reliable quantitative tool. Sarcopenia and visceral adiposity are linked to poor surgical outcomes, yet their roles in fracture healing remain unclear. This study hypothesizes that low skeletal muscle index (SMI) and high fat indices are associated with delayed healing. Methods: A total of 619 participants from two institutions were enrolled to assess the skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous fat area ratio (VSR) at the T12 level, and subsequently categorized into control and experimental groups based on one-month postoperative RUSH scores (≥18 vs <18). Fracture healing was quantified using RUSH scores assessed by six blinded orthopedists (ICC = 0.824 at one month). At the same follow-up, a higher RUSH score was interpreted as faster fracture healing, whereas a lower score indicated delayed healing. Slower healing was defined as a RUSH score of less than 18 at one month. Results: Multicenter analysis demonstrated that each unit increase in SMI was associated with a 10–29.4% reduction in the risk of slower healing (Institution 1: OR = 0.900, 95% CI: 0.859–0.942; Institution 2: OR = 0.706, 95% CI: 0.610–0.818), whereas each unit increase in VFI was associated with a 1.7–6.4% increase in risk (OR = 1.021–1.064). In both institutions, the change in RUSH score from 1 day to 1 month was positively correlated with SMI and negatively correlated with VFI, with stronger associations observed in Institution 1 (r = 0.591, p < 0.001; r = −0.438, p < 0.001). ROC analyses confirmed that SMI had better discrimination (AUC = 0.682–0.862) compared with VFI (AUC = 0.614–0.691). Conclusion: Preoperative T12-level SMI and VFI were associated with the rate of fracture healing after adjustment, with lower SMI and higher VFI linked to slower healing.

Keywords: Intertrochanteric fracture, Skeletal muscle index, Sarcopenia, computed tomography, Fracture Healing

Received: 24 Aug 2025; Accepted: 07 Oct 2025.

Copyright: © 2025 Li, Huang, Tang, Jin, Zhang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yingze Zhang, yzling_liu@163.com
Jiasen Hu, 949533831@qq.com

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