ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1699166
Retrospective Analysis of Dietary Fat Quality and Cardiovascular Disease Risk Markers in Middle-Aged Adults
Provisionally accepted
- The Affiliated Chest Hospital of Zhengzhou University, Zhengzhou, China
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Background: The quality of fat in food affects the cardiovascular system by means of inflammatory and lipid pathways. Objective: To assess the relationship among middle-aged persons' cardiovascular disease (CVD) risk indicators and the composition of their dietary fat. Methodology: Two hundred adults (aged 40–65) from the Henan Provincial Chest Hospital's databases were incorporated in this retrospective, hospital-based observational investigation. Dietary consumption information was taken from food frequency questionnaires that had been filled out and were kept in medical records. Employing the unsaturated-to-saturated fatty acid proportion (UFA: SFA), dietary fat composition was measured and subjects were separated into tertiles. Anthropometric variables, lipid levels (total cholesterol, LDL-C, HDL-C), and inflammation levels (hs-CRP) were obtained from pre-existing laboratory and hospital records. Results: In comparison to the lowest tertile, the highest UFA:SFA tertile had greater HDL-C (+8.29 mg/dL, d = 1.54), decreased TC (−30.33 mg/dL, d = 2.86), LDL-C (−24.73 mg/dL, d = 2.67), and hs-CRP (−1.28 mg/L, d = 2.53; all p < 0.001). Conclusion: Better lipid and inflammatory levels were associated with higher dietary fat quality, highlighting the significance of substituting unsaturated fats for saturated fats as a CVD prevention measure. However, prospective or interventional research are required to investigate causal effects, as these results are observational and demonstrate association rather than causality.
Keywords: Fat quality index, Cardiovascular biomarkers, Hyperlipidemia, Inflammation, Health
Received: 05 Sep 2025; Accepted: 17 Oct 2025.
Copyright: © 2025 Zhang, Wang, Huang, Li and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changchun Du, kisioa@163.com
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