REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1699218
Association between Chronic Kidney Disease and Sarcopenia and Emerging Treatment Strategies
Provisionally accepted
- Jilin University, Changchun, China
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Chronic kidney disease (CKD) is an irreversible and progressive kidney disease with a significant global health impact. Sarcopenia is an age-related syndrome characterized by the progressive loss of skeletal muscle mass and strength, and it exhibits a high prevalence, particularly among the elderly. There is a growing body of evidence indicating a strong bidirectional association between CKD and Sarcopenia. The prevalence of sarcopenia is significantly higher in CKD patients and increases as kidney function deteriorates. This review examines the potential relationship between CKD and sarcopenia, discusses their pathophysiological mechanisms, including chronic inflammation, oxidative stress, uremic toxin accumulation, metabolic acidosis, and hormonal disorders, and explores their clinical implications. Additionally, this review aims to elucidate potential pathogenic mechanisms and propose preventive and therapeutic strategies for CKD and sarcopenia, thereby guiding the optimization of clinical management and slowing disease progression.
Keywords: CKD, Sarcopenia, chronic inflammation, Oxidative Stress, Uremic toxin, metabolicacidosis, Hormone disorders
Received: 05 Sep 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Li, Cao, Gao, Liang, Ma, Liu, Wang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Wei, weiw@jlu.edu.cn
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