ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Food Science Technology
Phenolic profile of different solvent extracts of Reseda alba L. and evaluation of anti-quorum-sensing, antioxidant and enzymes inhibition activities
Provisionally accepted
Mohammed Nacer1Sameh Boudiba1Alfred Ngenge Tamfu2Ali Kalla1Karima Hanini1Louiza Boudiba1
Mohammed Messaoudi3
Ayomide Victor Atoki4*Selcuk Kucukaydin5Soraya Hioun1Khattabi Latifa6Ozgur Ceylan5- 1Universite Echahid Cheikh Larbi Tebessi, Tebessa, Algeria
- 2Universite de Ngaoundere, Ngaoundere, Cameroon
- 3Laboratoire de Recherche sur les Produits Bioactifs et Valorisation de la Biomasse, Alger, Algeria
- 4Kampala International University Western Campus, Kampala, Uganda
- 5Mugla Sitki Kocman Universitesi, Mugla, Türkiye
- 6Centre de Recherche en Biotechnologie, Constantine, Algeria
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Abstract Background: Reseda alba (white mignonette) is a wild, edible, and medicinal plant native to the Mediterranean region, with limited studies on its chemical composition and bioactivities. Methods: The phenolic profile and bioassays of antioxidant, anti-swarming, quorum-sensing (QS), and enzyme-inhibitory activities of different solvent extracts of Reseda alba are investigated using HPLC-DAD. Results: Rosmarinic acid was identified as the predominant phenolic compound in the ethyl acetate extract (197.5 ± 0.25 µg/g) and n-butanol extract (205.4 ± 0.47 µg/g). Minimal inhibitory concentrations (MIC) ranged from 0.3125 to 2.5 mg/mL against Chromobacterium violaceum and Pseudomonas aeruginosa PA01. These extracts demonstrated significant inhibition of quorum sensing and swarming motility against C. violaceum and P. aeruginosa PA01 at MIC and sub-MIC. Extracts exhibited inhibition of enzymes, especially cholinesterases implicated in neurodegenerative diseases. The extracts demonstrated antioxidant activity, as determined through six assays, with the dichloromethane extract (DCME) exhibiting higher antioxidant activity compared to the standards α-tocopherol and ascorbic acid in the FRAP assay. Conclusion: The results demonstrate that Reseda alba extracts possess significant inhibitory effects on enzymes implicated in neurodegenerative disorders such as Alzheimer's disease, particularly through butyrylcholinesterase inhibition. Additionally, the extracts show promising anti-quorum-sensing and anti-swarming activities, which could reduce microbial virulence and biofilm formation, suggesting potential as alternative antimicrobial agents. The moderate antioxidant activity further supports its therapeutic potential. Overall, R. alba could be developed as a natural source for managing enzyme-related diseases and controlling bacterial infections by targeting microbial communication mechanisms..
Keywords: Medicinal legume, Reseda alba, Phenolic profile, Quorum-sensing Inhibition, Swarming inhibition, Enzymes inhibition, antioxidant activity
Received: 05 Sep 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Nacer, Boudiba, Tamfu, Kalla, Hanini, Boudiba, Messaoudi, Atoki, Kucukaydin, Hioun, Latifa and Ceylan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ayomide Victor Atoki, atokiav@kiu.ac.ug
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