REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Role of metabolic conditions in cardiorenal diseases: Initiating pathways and therapeutic targeting
Provisionally accepted
- The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, China
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Albuminuria, a core indicator of kidney injury, is closely associated with cardiovascular disease prognosis. Through multiple mechanisms, metabolic abnormalities, such as hyperglycemia, hyperuricemia, obesity, and dyslipidemia, contribute to the onset and progression of albuminuria and significantly increase the risk of adverse cardiovascular outcomes. Based on recent clinical studies and basic experimental evidence, this review systematically elucidates how metabolic conditions are involved in the relationship between albuminuria and cardiac prognosis, encompassing several mechanisms, including chronic inflammation, endoplasmic reticulum stress, renin–angiotensin–aldosterone system overactivation, hemodynamic alterations, vascular endothelial dysfunction, mitochondrial dysfunction, and lipotoxicity. Additionally, it explores clinical intervention strategies. This review underscores the pivotal role of metabolic conditions in driving cardiorenal diseases and outlines evidence-based strategies for clinical management.
Keywords: Metabolic conditions, Albuminuria, kidney injury, cardiovascular outcomes, Mechanism, intervention strategies
Received: 08 Sep 2025; Accepted: 04 Nov 2025.
Copyright: © 2025 Yeshun, Xu, Tu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenyan Gao, gaozhenyan80@163.com
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