REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Collagen Supplementation and Regenerative Health: Advances in Biomarker Detection and Smart Material Integration
Provisionally accepted
Tatjana Ivaskiene1*Jonas Viskelis2Paulina Streimikyte2Milda Savickaite1Ali Mobasheri1,3,4,5
Greta Kasputė1- 1State Research Institute Center for Innovative Medicine, Vilnius, Lithuania
- 2Lietuvos agrariniu ir misku mokslu centras, Akademija, Lithuania
- 3Oulun Yliopisto Syovan ja translationaalisen laaketieteen tutkimusyksikko, Oulu, Finland
- 4Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- 5Universite de Liege, Liège, Belgium
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Collagen, the most abundant structural protein in the human body, plays a key role in skin integrity, tissue repair, and extracellular matrix organization. With increasing consumer and clinical interest, collagen supplementation has expanded rapidly, yet scientific evidence supporting its efficacy in anti-aging and regenerative applications remains inconsistent. This review critically evaluates current evidence on oral collagen supplementation, integrating insights from over 60 clinical studies assessing its effects on skin aging, musculoskeletal health, and hair disorders. Emerging data suggest that hydrolyzed collagen peptides may improve skin elasticity, joint function, and recovery after exercise, particularly when co-supplemented with vitamin C, silica, or resveratrol. Beyond supplementation, recent advances in biosensing and material science have enabled novel approaches to collagen detection and targeted delivery. Electrochemical, optical, and molecularly imprinted polymer (MIP)-based biosensors facilitate real-time monitoring of collagen biomarkers such as CTX-I, MMPs, and hydroxyproline, supporting precision assessment of collagen metabolism. In parallel, collagen-based hydrogels, nanoparticles, and electroresponsive scaffolds have shown promise as biocompatible carriers for controlled drug release and regenerative therapy. Collectively, these developments outline a translational framework connecting collagen supplementation, detection, and delivery. Continued integration of biosensing and smart material technologies may enhance clinical monitoring and therapeutic efficacy, advancing collagen-based interventions toward precision dermatology and regenerative medicine.
Keywords: Collagen, Supplement, Clinical Trial, Biological effect, Biosensors, Drug Delivery Systems
Received: 30 Sep 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 Ivaskiene, Viskelis, Streimikyte, Savickaite, Mobasheri and Kasputė. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tatjana Ivaskiene, tatjana.ivaskiene@imcentras.lt
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.