PERSPECTIVE article
Front. Nutr.
Sec. Nutrition and Microbes
Postbiotics in Pediatric Clinical Practice: Position Paper from Special Group of LatinAmerican Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN)
Provisionally accepted
Rodrigo Vázquez-Frias1,2*
Gabriel Vinderola3
Ana Tereza Abreu y Abreu4Diana Angulo1,5Natasha Giler-Párraga1,6Liliana Ladino1,7Carolina Ortiz1,8Sebastián Pereira1,9
Juan Pablo Bustamante1,10,11*- 1LatinAmerican Society of Pediatric Gastroenterology, Hepatology and Nutrition, Mexico, Mexico
- 2Subdirección de Gestión de la Investigación, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico
- 3Instituto de Lactología Industrial (UNL-CONICET), Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santa Fe, Argentina
- 4Sociedad Mexicana de Microbiota, Ciudad de México, Argentina
- 5Hospital Nacional Docente Madre Niño “San Bartolomé", Lima, Peru
- 6Universidad de Las Americas, Quito, Ecuador
- 7Centro de Investigación y Educación en Nutrición CIENutrition, Bogotá, Colombia
- 8GastroCare for Kids, Ciudad de Guatemala, Guatemala
- 9Hospital General Pediátrico Niños de Acosta Ñu, Hospital Central del Instituto de Previsión Social, Asunción, Paraguay
- 10CONICET, Oro Verde, Argentina
- 11Facultad de Ingeniería, Universidad Nacional de Entre Ríos, Oro Verde, Argentina
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Postbiotics, defined by the ISAPP as preparations of inanimate microorganisms and/or their components that confer health benefits, represent a promising category of microbiome-derived solutions. This position paper highlights their clinical relevance, particularly in pediatrics, while addressing key aspects of definition, safety, quality, and strain-level specificity. Evidence supports the use of Lactobacillus LB —including L. fermentum CNCM I-2998 and L. delbrueckii subsp. lactis CNCM I-4831— in reducing the duration and severity of acute diarrhea in children. Other strains, such as Bifidobacterium breve C50, Streptococcus thermophilus 065, Lacticaseibacillus paracasei CBA L74, Lactiplantibacillus plantarum LPL28, and Ligilactobacillus salivarius AP-32, show promise in preventing infections, supporting oral health, and modulating immune responses. Additional postbiotics, including Limosilactobacillus reuteri DSM 17648, expand their potential into metabolic and gastrointestinal disorders. Collectively, postbiotics emerge as clinically valuable interventions, bridging science and medical practice.
Keywords: Postbiotics, pediatric, clinical practice, microbiome, Inactivated microorganisms
Received: 30 Sep 2025; Accepted: 04 Nov 2025.
Copyright: © 2025 Vázquez-Frias, Vinderola, Abreu y Abreu, Angulo, Giler-Párraga, Ladino, Ortiz, Pereira and Bustamante. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rodrigo Vázquez-Frias, rovaf@yahoo.com
Juan Pablo Bustamante, bustamante.bio@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.