Frontiers in Oncology | Cancer Molecular Targets and Therapeutics

Original Research

Published on 20 Nov 2025

Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phenotypes in colorectal cancer

in Cancer Molecular Targets and Therapeutics

Sha-Sha Hu
Tian-Yuan Tan
Wei Yan
Yu Wu
Xin-Nian Li
Fu-Jin Liu
Bo Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1583277

591 views

Case Report

Published on 20 Nov 2025

Genomic complexity in advanced gastric and esophageal adenocarcinomas: a case report of rare WDR11-AS1-FGFR2 fusions

in Cancer Molecular Targets and Therapeutics

Eric Mehlhaff
Dustin A. Deming
Jeremy D. Kratz
Khaldun Obeidat
Lauren Welch
Nataliya Uboha

Frontiers in Oncology

doi 10.3389/fonc.2025.1686070

161 views

Case Report

Published on 19 Nov 2025

Case Report: Should IGF-1R targeted therapy be revisited in Ewing sarcoma? a report of long-term complete response and review of the literature

in Cancer Molecular Targets and Therapeutics

Georgios M. Stergiopoulos
Brittany L. Siontis
Safia K. Ahmed
Judith Jebastin Thangaiah
Matthew T. Houdek
Thanh P. Ho
Scott H. Okuno
Steven I. Robinson

Frontiers in Oncology

doi 10.3389/fonc.2025.1667628

186 views

Review

Published on 19 Nov 2025

Advances in the study of FOXQ1: biological functions and mechanisms

in Cancer Molecular Targets and Therapeutics

Xiaojian Feng
Ling Zhang
Peiyao Shi
Yiping Hu

Frontiers in Oncology

doi 10.3389/fonc.2025.1650022

104 views

Case Report

Published on 19 Nov 2025

Partial response in a patient with skeletal and hepatic metastases following resected pancreatic cancer to the novel cell therapy SL-28: a case report

in Cancer Molecular Targets and Therapeutics

Victor Tetz
Kristina Kardava
Olzhas Shulenbayev
Maria Vecherkovskaya
Alireza Khodadadi-Jamayran
Aristotelis Tsirigos
George Tetz

Frontiers in Oncology

doi 10.3389/fonc.2025.1636989

297 views

Review

Published on 19 Nov 2025

Targeting TEAD in cancer

in Cancer Molecular Targets and Therapeutics

Rohith Battina
Raneen Rahhal
Anton Wellstein
Anna T. Riegel
Ghada M. Sharif

Frontiers in Oncology

doi 10.3389/fonc.2025.1692512

244 views

Original Research

Published on 19 Nov 2025

Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling

in Cancer Molecular Targets and Therapeutics

Yujie Shi
Peijia Niu
Qiong Cheng
Lexia Chen
Yahan Weng
Xiaohe Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1631415

435 views

Original Research

Published on 19 Nov 2025

CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors

in Cancer Molecular Targets and Therapeutics

Nawel Zouggari
Camilla Trugenberger
Valentine Du Bois
Wenwen Wang
Giacomo G. Rossetti
Thanos D. Halazonetis
Intidhar Labidi-Galy

Frontiers in Oncology

doi 10.3389/fonc.2025.1626301

314 views

Brief Research Report

Accepted on 18 Nov 2025

TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease

in Cancer Molecular Targets and Therapeutics

Alexander B. Sigalov

Frontiers in Oncology

124 views

Case Report

Accepted on 18 Nov 2025

TP53 Heterogeneous Alteration in Grade 3 Type Ⅰ Gastric NET: A Case Implicating Primary Tumor Progression

in Cancer Molecular Targets and Therapeutics

Yan Li
Yuekui Bai
Hongjuan Ti
Chunyu Zhou
Qian Liu
Ying Dong

Frontiers in Oncology

Original Research

Published on 18 Nov 2025

Prognostic alternative mRNA splicing in lung adenocarcinoma

in Cancer Molecular Targets and Therapeutics

Panke Su
Pei Xu
Deying Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1579017

477 views

Systematic Review

Accepted on 17 Nov 2025

The efficacy and safety of ATR inhibitors in the treatment of solid tumors: a systematic review and meta-analysis

in Cancer Molecular Targets and Therapeutics

Yaxu Su
Xinyu Lu
Zhenzhen Bu
Xue Yang
Ping Liu

Frontiers in Oncology

103 views

Original Research

Accepted on 17 Nov 2025

Mechanistic Role of CD82 Palmitoylation in Augmenting Antitumor Drug Sensitivity via Apoptosis Regulation

in Cancer Molecular Targets and Therapeutics

Lanyan Li
Yaning Yu
Sirui Chen
Yihuan Zhang
Can Zhang
Xinyu Yao
Hongli Xu
Shihao Wu
Xue Gong
Weiping Han

Frontiers in Oncology

Original Research

Accepted on 17 Nov 2025

Targeting Endoplasmic reticulum Stress-Induced CLGN Resensitizes Hepatocellular Carcinoma to Apoptosis: Paeonol Synergistically Enhances Efficacy by Dual Inhibition of CLGN and NF-κB

in Cancer Molecular Targets and Therapeutics

Sitong Yan
Anqi Wang
Xiang Chen
Weijia Jiang
Xiao Du
Yuhan Huang
Xiangyu Zu
Yue Zhu
Jiatao Liu
Lulu Fan

Frontiers in Oncology

Systematic Review

Accepted on 17 Nov 2025

Efficacy and Safety of Anlotinib for the Treatment of Advanced Bone and Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis

in Cancer Molecular Targets and Therapeutics

Zhipeng Li
Peng Fang
Shiwen Shen
Lei Zhang
Rui Xie
Chengjun Li

Frontiers in Oncology

Review

Accepted on 17 Nov 2025

Sleepyhead, deadly awakening: the dynamics of metastatic organotropism, tumor dormancy and therapeutic implications

in Cancer Molecular Targets and Therapeutics

Soumyajit Sarkar
Suresh P.K.

Frontiers in Oncology