Frontiers in Oncology | Cancer Molecular Targets and Therapeutics

Original Research

Published on 12 Aug 2026

Circulating methylated promoters of HK2 and EGFR as biomarkers in the early detection of cancer

in Cancer Molecular Targets and Therapeutics

Mythreyi Jannu
Ramesh Ummanni
Rajeswari Jinka

Frontiers in Oncology

doi 10.3389/fonc.2026.1847436

175 views

Case Report

Accepted on 11 Aug 2026

Case Report: Treatment of an unresectable mucoepidermoid carcinoma with osimertinib

in Cancer Molecular Targets and Therapeutics

Leonardo Villa Ferreira
Alice Soares
Haoone Abboud
Viviane Basílio
Daniel Herchenhorn

Frontiers in Oncology

Original Research

Accepted on 11 Aug 2026

ANP32A Interacts with LDHA to Modulate Glycolysis and Ferroptosis in Hepatocellular Carcinoma

in Cancer Molecular Targets and Therapeutics

Bixia Chi
Zhi Cui
Xinyue Hou
Hongfang Ding
LinJun Li
Rui Ai
Yizhuang Yang
Yue Zhao
Liyan Wang
Juan Wang

Frontiers in Oncology

Original Research

Published on 11 Aug 2026

RPLP0 identified as a ferroptosis regulator in HCC through pan-cancer analysis

in Cancer Molecular Targets and Therapeutics

Zuli Wang
Shuai Chen
Bokang Yan
Xintong Peng
Ling Chen
Min Su
Haiyang Li

Frontiers in Oncology

doi 10.3389/fonc.2026.1891222

392 views

Case Report

Accepted on 10 Aug 2026

Tyrosine Kinase Inhibitors in ROS1-rearranged and Granulocyte Colony-Stimulating Factor-Producing Lung Squamous Cell Carcinoma: A Case Report

in Cancer Molecular Targets and Therapeutics

Ruijie Li
Shengjie Zhang
Zhenghe Liu
Xuan Wu

Frontiers in Oncology

Review

Published on 10 Aug 2026

Molecular mechanisms of therapeutic resistance in areca nut–associated oral squamous cell carcinoma: the interplay of chronic inflammation and epithelial–mesenchymal transition

in Cancer Molecular Targets and Therapeutics

Kaushik Joshi
Arya P. R.
Dipali Raju
Shilpa H. D.
Vijetha Shenoy Belle
Naveena A. N. Kumar
Mehta Vedant Kamal

Frontiers in Oncology

doi 10.3389/fonc.2026.1906691

267 views

Original Research

Accepted on 07 Aug 2026

Therapeutic efficacy of hispidulin-loaded carboxymethyl cellulose nanoparticles against mammary carcinogenesis through ROS-mediated apoptosis and tissue remodelling

in Cancer Molecular Targets and Therapeutics

Vrushali Manoj Hadkar
Chinnadurai Immanuel Selvaraj

Frontiers in Oncology

484 views

Review

Published on 07 Aug 2026

Photodynamic therapy: a promising alternative for high-grade squamous intraepithelial lesion treatment

in Cancer Molecular Targets and Therapeutics

Lara Termini
Cristina Paula Castanheira
Noely Paula Cristina Lorenzi
Enrique Boccardo
Telma Lisboa-Nascimento
Maurício S. Baptista
Natalia Mayumi Inada
Waleska Kerllen Martins

Frontiers in Oncology

doi 10.3389/fonc.2026.1899399

481 views

Mini Review

Published on 07 Aug 2026

The heterogeneous and dynamic immune-tumor interface in breast cancer

in Cancer Molecular Targets and Therapeutics

Constantin N. Baxevanis
Maria Goulielmaki
Angelos D. Gritzapis
Ourania E. Tsitsilonis

Frontiers in Oncology

doi 10.3389/fonc.2026.1906555

208 views

Original Research

Published on 06 Aug 2026

Targeting ADAR stability: a novel approach to combat glioblastoma

in Cancer Molecular Targets and Therapeutics

Qin Fei
Jueru Huang
Yufeng Zhang
Yi He
Qiang Fu

Frontiers in Oncology

doi 10.3389/fonc.2026.1827793

475 views

Review

Accepted on 05 Aug 2026

Resistance Mechanisms and Countermeasures in CLDN18.2-Positive Tumors: From Molecular Networks to Clinical Practice

in Cancer Molecular Targets and Therapeutics

Yutao Xia
Kai Sun
Mingfang Wang
Taosheng Huang
Peng Wang

Frontiers in Oncology

113 views

Original Research

Accepted on 05 Aug 2026

Efferocytosis related KCTD12 is a clinico-immune target in lung adenocarcinoma

in Cancer Molecular Targets and Therapeutics

Wen Shan
Guanya Cao
Yu Liu
Yifei Zhu

Frontiers in Oncology

Original Research

Accepted on 05 Aug 2026

A pretreatment multiphasic CT-based decision-support model for differentiating pediatric hepatoblastoma from focal nodular hyperplasia

in Cancer Molecular Targets and Therapeutics

Lizhu Cai
Yun Peng

Frontiers in Oncology

Original Research

Published on 05 Aug 2026

LncTRDMT1–5 promotes chromosomal instability through MSRB3-mediated cell cycle and DNA damage in breast cancer

in Cancer Molecular Targets and Therapeutics

Qi Chen
Yunpeng Chen
Hui Yang
Xiaolan Zhu

Frontiers in Oncology

doi 10.3389/fonc.2026.1899923

258 views

Original Research

Accepted on 04 Aug 2026

Profibrogenic GREMLIN1 Expression in Prostate Cancer and the Clinicopathologic Association

in Cancer Molecular Targets and Therapeutics

Danqing Ren
Yu-Hsuan Chien
Reina Xu
Kai-Yuan Tsung
Gustavo E. Ayala
Tien C. Ko
Yanna Cao
Run Wang
Tung Shu

Frontiers in Oncology

127 views

Original Research

Published on 04 Aug 2026

Comparative clinical and prognostic significance of integrin αvβ3, αvβ5, and αvβ6 in osteosarcoma

in Cancer Molecular Targets and Therapeutics

Chaoqun You
Fanwei Zeng
Shuai Zhang
Jiuhui Xu
Tingting Ren
Lu Xie
Yuchen Song
Xiaodong Tang
Ran Wei

Frontiers in Oncology

doi 10.3389/fonc.2026.1888679

542 views

Original Research

Accepted on 03 Aug 2026

Multi-omics Screening and Functional Validation Identify SLC5A6 as a Candidate Disulfidptosis-Related Gene and Prognostic Biomarker in Hepatocellular Carcinoma

in Cancer Molecular Targets and Therapeutics

Chong Fu
Zejing Fang
Yanping Zhang
Wei Xu

Frontiers in Oncology

279 views

Review

Accepted on 03 Aug 2026

Role of Health Digital Twins in Oncology Drug Development - A Primer

in Cancer Molecular Targets and Therapeutics

MARIA GARCIA REQUESENS
Arun Mankan
Luca Cantini
Marco Calabresi
Laura Vidal
Joanie Brown
Steven Lang
Bobby Kaura
Kirill Veselkov
Ioannis Xenarios

Frontiers in Oncology

243 views

Review

Accepted on 31 Jul 2026

The electrical tumor microenvironment: abnormalities and opportunities

in Cancer Molecular Targets and Therapeutics

Alice Burchett Darantiere
Fionn Lay
Meenal Datta

Frontiers in Oncology

166 views

Perspective

Published on 31 Jul 2026

MCL-1 as a tumor microenvironment-linked survival node in cholangiocarcinoma

in Cancer Molecular Targets and Therapeutics

Hiroki Hashida
Atsushi Kobayashi
Masatoshi Akagami
Tomohiro Okamoto
Hirokazu Tanaka

Frontiers in Oncology

doi 10.3389/fonc.2026.1892339

377 views

Systematic Review

Accepted on 30 Jul 2026

Uncharted phytochemical frontiers: A systematic review of novel bioactive compounds from underexplored aromatic plants for cancer therapy

in Cancer Molecular Targets and Therapeutics

Biswabhusan Dash
Himadri Tanaya Behera
NG Unnoottee
Swagat Mohanty
Divaker Shukla
Sudipta Jena
Asit Ray
Pratap Chandra Panda
Sanghamitra Nayak
Ambika Sahoo

Frontiers in Oncology

149 views

Review

Accepted on 30 Jul 2026

Artificial Intelligence-Assisted Photodynamic Diagnosis and Photodynamic Therapy against Cancer

in Cancer Molecular Targets and Therapeutics

Jinju Huang
Siu Kan Law
Albert Wing Nang Leung
Chuanshan Xu

Frontiers in Oncology

203 views

Original Research

Accepted on 30 Jul 2026

Umbralisib Antagonizes Multidrug Resistance in ABCB1-Overexpressing Cancer Cells

in Cancer Molecular Targets and Therapeutics

Letao Bo
Bohan Zhang
Xuan-Yu Chen
Xuanming Mao
Luke Zhong
Meizi Tan
Mingyu Cui
Harsh Patel
John N. D. Wurpel
Zhe-Sheng Chen

Frontiers in Oncology

140 views

Case Report

Accepted on 29 Jul 2026

Marked Response to Dabrafenib Plus Trametinib in a Patient with BRAF V600E-Mutant Pancreatic Hepatoid Carcinoma: A Case Report and Systematic Analysis of 57 Cases

in Cancer Molecular Targets and Therapeutics

Yingli Li
Shengzhi Xie
Xianchang Sun
Fangwei Wang
Hanbing Guo
Di Chen
Jianhua Dang
Xiaoli Yang
Yufei Wang
Ma Xueping

Frontiers in Oncology

144 views