CASE REPORT article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Diagnosis of Salmonella enterica-Induced Septic Arthritis in a Healthy Child Using Metagenomic Next-Generation Sequencing: A Case Report
Provisionally accepted
Min Ren
Qiong Liao*- Sichuan University West China Second University Hospital, Chengdu, China
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Salmonella enterica-induced arthritis frequently manifests in children with malignancies, sickle cell disease, immunodeficiency, or undergoing immunosuppressive therapy; however, its incidence in healthy children is rare. Here, we present a case of septic arthritis resulting from S. enterica infection in a previously healthy child, diagnosed utilizing metagenomic next-generation sequencing (mNGS). This case underscores the utility of mNGS in the clinical identification of S. enterica arthritis. Particularly in scenarios where the causative pathogen remains unidentified, mNGS emerges as a pivotal adjunctive diagnostic modality for uncommon pathogens.
Keywords: MNGs, Salmonella enterica, septic arthritis, Healthy child, case report
Received: 12 Sep 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Ren and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiong Liao, 33765410@qq.com
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