Frontiers in Pediatrics | Pediatric Hematology and Hematological Malignancies

Original Research

Accepted on 10 Feb 2026

Development of a risk prediction model for central venous catheter insertion-related thrombosis in critically ill pediatric patients

in Pediatric Hematology and Hematological Malignancies

Xiaolan Zhou
Yunrong Li
Shoushan Chen
Yingbo Zou
Huan Wang
Li Lei

Frontiers in Pediatrics

Case Report

Accepted on 27 Jan 2026

Management of Multiple Drug Hypersensitivity in a Child with Very Severe Aplastic Anemia: A Case Report and Therapeutic Challenge

in Pediatric Hematology and Hematological Malignancies

Meihua Chen
Yi Deng
Pengyu Bin
Rong Gao
Nan Liao
Zhilin Zhou
Xin Huang
Jiaojiao Li
Jingsong Wang

Frontiers in Pediatrics

169 views

Systematic Review

Accepted on 26 Jan 2026

Criteria for Unmet Need in Paediatric Populations and Their Families: A Literature-Based Case Study in Haematological Malignancies In Upper-Middle and High-Income Countries

in Pediatric Hematology and Hematological Malignancies

Charlotte Van Isterdael
Zilke Claessens
Isabelle Huys

Frontiers in Pediatrics

145 views

Review

Published on 13 Jan 2026

Current research status of third-generation sequencing technology in thalassemia detection

in Pediatric Hematology and Hematological Malignancies

Fenglin Zhu
Yunli Lai
Sheng He

Frontiers in Pediatrics

doi 10.3389/fped.2025.1705599

656 views

Brief Research Report

Published on 12 Jan 2026

Outcomes of T-cell lymphoblastic lymphoma in children and adolescents treated with Dana-Farber Cancer Institute Childhood ALL Consortium protocols

in Pediatric Hematology and Hematological Malignancies

Giacomo Gotti
Yael Flamand
Victoria Koch
Sabrina Testa
Kristen Stevenson
Thai-Hoa Tran
Bruno Michon
Uma Athale
Lewis B. Silverman
Yana Pikman

Frontiers in Pediatrics

doi 10.3389/fped.2025.1686081

921 views

Case Report

Published on 08 Jan 2026

Case Report: Early diagnostic precision matters: navigating therapeutic uncertainty in pediatric BPDCN illustrated by misdiagnosis sequelae and fleeting CAR-T response

in Pediatric Hematology and Hematological Malignancies

XiaoYan Chen
JiaYi Wang
WenGe Hao
YuHua Qu
Xiaojing Wang
Hua Jiang
WeiNa Zhang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1710591

567 views

Original Research

Published on 07 Jan 2026

Influence of white blood cell count trajectories on the risk of differentiation syndrome during induction therapy with all-trans-retinoic acid and arsenic trioxide in pediatric acute promyelocytic leukemia

in Pediatric Hematology and Hematological Malignancies

Houxin Fu
Yuchen Liu
Shaoyan Hu

Frontiers in Pediatrics

doi 10.3389/fped.2025.1742083

604 views

Brief Research Report

Published on 06 Jan 2026

Risk factors for venous thromboembolism in Slovenian children and adolescents: a single center experience

in Pediatric Hematology and Hematological Malignancies

Mineja Leban
Marko Kavčič
Jakob Peterlin
Janez Jazbec
Barbara Faganel Kotnik

Frontiers in Pediatrics

doi 10.3389/fped.2025.1729489

635 views

Case Report

Published on 19 Dec 2025

Congenital factor XIII deficiency caused by F13A1 gene mutations presenting with intracranial hemorrhage: a case report

in Pediatric Hematology and Hematological Malignancies

Hao Wang
Ruotong Yang
Jianchang Li

Frontiers in Pediatrics

doi 10.3389/fped.2025.1732065

1,019 views

Original Research

Published on 18 Dec 2025

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

in Pediatric Hematology and Hematological Malignancies

XiaoYan Chen
LingLing Wu
CaiYun Kuang
JiaYi Wang
WenGe Hao
Hua Jiang
WeiNa Zhang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1710578

1,719 views

Original Research

Published on 17 Dec 2025

Optimizing nursing care in phototherapy to improve treatment outcomes in neonatal jaundice management

in Pediatric Hematology and Hematological Malignancies

Qian Dong
Fan Huang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1652188

1,490 views

Original Research

Published on 16 Dec 2025

Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants

in Pediatric Hematology and Hematological Malignancies

Danni Li
Meiling Liao
Yuye Liu
Luying Zhang
Yingxue Hong
Yuxia Guo
Xianmin Guan
Ying Dou
Xianhao Wen

Frontiers in Pediatrics

doi 10.3389/fped.2025.1700402

1,278 views

Review

Published on 16 Dec 2025

Mixed phenotype acute leukemia, the dissection of an enigmatic disease in the era of novel therapies

in Pediatric Hematology and Hematological Malignancies

Magdalena Karasek
Izabela Kubiszewska
Marta Sobas

Frontiers in Pediatrics

doi 10.3389/fped.2025.1715087

1,632 views

Original Research

Published on 12 Dec 2025

P2RX1 promotes mitochondrial apoptosis via calcium/CaM KII-mediated suppression of PI3K/Akt signaling in Philadelphia chromosome-positive acute lymphoblastic leukemia

in Pediatric Hematology and Hematological Malignancies

Xiao bing Li
Qin Ren
Xiang mei Ye
Jing lie Li
Lei guang Feng

Frontiers in Pediatrics

doi 10.3389/fped.2025.1730429

1,001 views

Editorial

Published on 04 Dec 2025

Editorial: Diagnosis and therapy pediatric hematological malignancies—recent progress—volume II

in Pediatric Hematology and Hematological Malignancies

Joanna Zawitkowska
Monika Lejman
Katarzyna Derwich

Frontiers in Pediatrics

doi 10.3389/fped.2025.1749385

832 views

Case Report

Published on 26 Nov 2025

Case Report: A case report and literature review of shwachman-diamond syndrome concurrent with klinefelter syndrome

in Pediatric Hematology and Hematological Malignancies

Chenyang Chang
Hao Chen
Hao Zhang
Jingshan Chen
Qinxin Wan
Huifang Zhu
Kaiyuan Luo
Xingyu Rao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1671169

1,150 views

Case Report

Published on 11 Nov 2025

Hemophagocytic lymphohistiocytosis as the initial manifestation of Epstein–Barr virus-related T/NK-cell lymphoproliferative disorders in a pediatric patient: a case report and literature review

in Pediatric Hematology and Hematological Malignancies

Lianwei Ma
Xue Xing
Yonge Liu
Wei Jiang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1662074

1,953 views

Original Research

Published on 06 Nov 2025

Clinical analysis of secondary hemophagocytic syndrome in children in Gansu province

in Pediatric Hematology and Hematological Malignancies

Yongkang Zhou
Junqiang Yang
Zhongbin Tao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1660880

1,706 views

Case Report

Published on 27 Oct 2025

Case Report: Autoimmune hemolytic anemia associated with ovarian teratoma in a 13-year-old: a rare paraneoplastic presentation

in Pediatric Hematology and Hematological Malignancies

Salman Althobaiti
Ahmad Assinnari
Mayes Alharbi
Razan Kurdi

Frontiers in Pediatrics

doi 10.3389/fped.2025.1700443

1,394 views

Original Research

Published on 21 Oct 2025

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia

in Pediatric Hematology and Hematological Malignancies

Zhenzhen Zhu
Junchen Yan

Frontiers in Pediatrics

doi 10.3389/fped.2025.1665431

1,774 views

Case Report

Published on 10 Oct 2025

Case Report: Refractory systemic nmastocytosis with AML1::ETO+ acute myeloid leukemia driven by rare KIT mutation: remarkable therapeutic efficacy of avapritinib

in Pediatric Hematology and Hematological Malignancies

Song Xue
Man Chen
Hui-peng Sun
Xing-yu Cao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1646001

2,113 views

Original Research

Published on 03 Oct 2025

Study on the influencing factors of the first-line treatment response to primary immune thrombocytopenia in children

in Pediatric Hematology and Hematological Malignancies

Bihan Zhang
Qian Hu
Qiaodao Wu
Jianying Ning

Frontiers in Pediatrics

doi 10.3389/fped.2025.1679463

2,312 views

Mini Review

Published on 12 Sep 2025

Revisiting cytomegalovirus in pediatric allogeneic hematopoietic stem cell transplant recipients: current strategies for prevention and management in the letermovir era

in Pediatric Hematology and Hematological Malignancies

Lisa Hiskey
Diego R. Hijano
Ramia Zakhour

Frontiers in Pediatrics

doi 10.3389/fped.2025.1663600

3,496 views

Case Report

Published on 04 Sep 2025

Case report: Successful treatment of a patient presenting with a very rare association of acute lymphoblastic leukemia and mucopolysaccharidosis type IVA

in Pediatric Hematology and Hematological Malignancies

Sofia Maria Carlotta Arnaboldi
Martha Caterina Faraguna
Antonella Colombini
Alessandra Sala
Veronica Leoni
Marco Spinelli
Giacomo Gotti
Laura Rachele Bettini
Viola Crescitelli
Anna Commone

Frontiers in Pediatrics

doi 10.3389/fped.2025.1644720

2,336 views

294 articles

articles

Development of a risk prediction model for central venous catheter insertion-related thrombosis in critically ill pediatric patients

Management of Multiple Drug Hypersensitivity in a Child with Very Severe Aplastic Anemia: A Case Report and Therapeutic Challenge

Criteria for Unmet Need in Paediatric Populations and Their Families: A Literature-Based Case Study in Haematological Malignancies In Upper-Middle and High-Income Countries

Current research status of third-generation sequencing technology in thalassemia detection

Outcomes of T-cell lymphoblastic lymphoma in children and adolescents treated with Dana-Farber Cancer Institute Childhood ALL Consortium protocols

Case Report: Early diagnostic precision matters: navigating therapeutic uncertainty in pediatric BPDCN illustrated by misdiagnosis sequelae and fleeting CAR-T response

Influence of white blood cell count trajectories on the risk of differentiation syndrome during induction therapy with all-trans-retinoic acid and arsenic trioxide in pediatric acute promyelocytic leukemia

Risk factors for venous thromboembolism in Slovenian children and adolescents: a single center experience

Congenital factor XIII deficiency caused by F13A1 gene mutations presenting with intracranial hemorrhage: a case report

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

Optimizing nursing care in phototherapy to improve treatment outcomes in neonatal jaundice management

Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants

Mixed phenotype acute leukemia, the dissection of an enigmatic disease in the era of novel therapies

P2RX1 promotes mitochondrial apoptosis via calcium/CaM KII-mediated suppression of PI3K/Akt signaling in Philadelphia chromosome-positive acute lymphoblastic leukemia

Editorial: Diagnosis and therapy pediatric hematological malignancies—recent progress—volume II

Case Report: A case report and literature review of shwachman-diamond syndrome concurrent with klinefelter syndrome

Hemophagocytic lymphohistiocytosis as the initial manifestation of Epstein–Barr virus-related T/NK-cell lymphoproliferative disorders in a pediatric patient: a case report and literature review

Clinical analysis of secondary hemophagocytic syndrome in children in Gansu province

Case Report: Autoimmune hemolytic anemia associated with ovarian teratoma in a 13-year-old: a rare paraneoplastic presentation

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia

Case Report: Refractory systemic nmastocytosis with AML1::ETO+ acute myeloid leukemia driven by rare KIT mutation: remarkable therapeutic efficacy of avapritinib

Study on the influencing factors of the first-line treatment response to primary immune thrombocytopenia in children

Revisiting cytomegalovirus in pediatric allogeneic hematopoietic stem cell transplant recipients: current strategies for prevention and management in the letermovir era

Case report: Successful treatment of a patient presenting with a very rare association of acute lymphoblastic leukemia and mucopolysaccharidosis type IVA