Frontiers in Pharmacology | Cardiovascular and Smooth Muscle Pharmacology

Editorial

Published on 15 Jun 2026

Editorial: Innovative approaches and molecular mechanisms in cardiovascular pharmacology

in Cardiovascular and Smooth Muscle Pharmacology

Maria Luiza S. Silva
Cristal J. Toghi
Carlos Alan C. Dias-Junior

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1857987

406 views

Original Research

Published on 15 Jun 2026

Activation of BK channels ameliorates cardiac injury Via NFκB-NLRP3 signaling in angiotensin II-induced hypertension mouse model

in Cardiovascular and Smooth Muscle Pharmacology

Long Zhao
Xingchen Wu
Xiaomao Luo
Anwen Zheng
Qiang Yue
Haidong Wang
Junko Ishida
Cesar A. Romero
Douglas C. Eaton
Janet D. Klein

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1739677

681 views

Original Research

Accepted on 12 Jun 2026

Investigation of Potential Sex-Based Differences in Trastuzumab-Induced Chronic Cardiotoxicity in a Rat Model

in Cardiovascular and Smooth Muscle Pharmacology

Réka Losonczi
Zsolt Galla
Merse Kis
Klaudia Kupecz
Dávid Volford
Andrea Siska
Réka Somogyi
Imre Földesi
Gabor Cserni
András Kriston

Frontiers in Pharmacology

Review

Accepted on 12 Jun 2026

Ferroptosis Regulation in Doxorubicin-Induced Cardiotoxicity: Multi-Mechanism Interventions and Translational Strategies

in Cardiovascular and Smooth Muscle Pharmacology

Xiaojie Chen
Yuyuan Lu
Yiyuan Wang
YuShun Kou
Yuanhui Gu
Lin Yi

Frontiers in Pharmacology

Original Research

Published on 12 Jun 2026

Curcumin protects high glucose-induced diabetic myocardial injury by regulating Nrf2 and PI3K/AKT pathways

in Cardiovascular and Smooth Muscle Pharmacology

ZeYue Xu
ZhuangYin Qu
Xia Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1752397

615 views

Case Report

Published on 11 Jun 2026

From heart to brain: a Case Report of individualized antithrombotic management for left ventricular thrombus and stroke in a young patient with acute myocardial infarction

in Cardiovascular and Smooth Muscle Pharmacology

Jincheng Wang
Xi Zhang
Qing Jin
Qiu Chen
Fuding Guo
Qiang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1829968

306 views

Original Research

Accepted on 10 Jun 2026

TRAF6 promotes pulmonary hypertension by enhancing K63-linked ubiquitination and activation of STAT3

in Cardiovascular and Smooth Muscle Pharmacology

Meijing Yao
Rui Chen
Mengran Shen
Zhengqiu Xu
Wei He
Bingbing Li

Frontiers in Pharmacology

Review

Accepted on 08 Jun 2026

Long-term efficacy and safety of solifenacin, mirabegron, and their combination for overactive bladder: a systematic review

in Cardiovascular and Smooth Muscle Pharmacology

Linlin Yang
Hongqiao Zhao
Shuna Xiao
Ziqi Ye

Frontiers in Pharmacology

132 views

Original Research

Published on 05 Jun 2026

Real-world bleeding risk and molecular interaction profiles of direct oral anticoagulants: a comparative study integrating clinical outcomes and in silico docking

in Cardiovascular and Smooth Muscle Pharmacology

Lutfi Cagatay Onar
Ersin Guner
Ibrahim Yilmaz

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1828307

937 views

Review

Published on 04 Jun 2026

A comprehensive review of ischemic heart disease: pathophysiology, current treatments, natural products-based therapies, and nanotherapeutics

in Cardiovascular and Smooth Muscle Pharmacology

Amr M. Saadeldeen
Abdallah Mansour
Ahmed M. El-Dessouki
Sally A. Fahim
Abeer M. Shaheen
Rehab A. Ismail
Rania M. Salama
Riham A. El-Shiekh
Hazim O. Khalifa

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1834343

1,314 views

Review

Accepted on 03 Jun 2026

Direct NLRP3 Inflammasome Inhibitors for Cardiovascular Therapeutics: A Comparative Review of Synthetic and Natural Candidates

in Cardiovascular and Smooth Muscle Pharmacology

Dong Zhen
Chunyan Liu
Xiao Sun
Terigen Bao
Bo Wang
Kai Zheng
Zhe Wu
Xiaojun Chen
Guoyou Zhang

Frontiers in Pharmacology

307 views

Original Research

Accepted on 31 May 2026

CCR2⁺ Macrophages Are Required for Exercise-Induced Cardiac Remodeling

in Cardiovascular and Smooth Muscle Pharmacology

Benjamin Kopecky
Gianni Bonnici
Tristan Cobb
Camille Daigle
McKenna Burns
Maura Sticco-Ivins
Elizabeth Hardy
Hao Dun
Samantha Nelson
Brisa Peña

Frontiers in Pharmacology

205 views

Original Research

Accepted on 31 May 2026

PCSK9 inhibition alleviates sepsis-induced myocardial dysfunction by facilitating PINK1/Parkin-associated mitophagy

in Cardiovascular and Smooth Muscle Pharmacology

Jiancheng Lin
Zetao Pan
Jiayan Sun
Xiaowan Wang
Linna Zhang
Yuheng Ye
Di Yin
Qiang Guo
Qiang Guo

Frontiers in Pharmacology

215 views

Original Research

Accepted on 29 May 2026

Bisphenols-enhanced platelet aggregation via TP, P2Y12, PAR1 and PAR4 Receptors: A Thrombotic Legacy in a Plastic-Ubiquitous World

in Cardiovascular and Smooth Muscle Pharmacology

Opata E Kwame
Aurora De La Peña
Yesenia I Martinez-Jimenez
Mirthala Flores-Garcia
Emma S. Calderón-Aranda
Irene Lee-Rivera
ROCIO GOMEZ

Frontiers in Pharmacology

224 views

Original Research

Accepted on 29 May 2026

Differential Recovery of Ventricular Repolarization and Hemodynamics Following Bupivacaine and Ropivacaine Intoxication: The Impact of Lipophilicity on Lipid Emulsion Efficacy

in Cardiovascular and Smooth Muscle Pharmacology

Lucia Rodríguez-Rodríguez
Julio Orallo-Martínez1
Ignacio Fernandez
Elena Vazquez
Sergio Garcia-Ramos
Oscar Quintela
Begoña Bravo
Sara Alvarez_Zaballos
Maria José Anadón-Baselga
Matilde Zaballos Garcia

Frontiers in Pharmacology

182 views

Original Research

Published on 29 May 2026

Icariin attenuates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome through SIRT3-mediated TFAM deacetylation

in Cardiovascular and Smooth Muscle Pharmacology

Min Sun
Hui Huang
Chao Wei
Yuan Xing
Bing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1829772

737 views

Original Research

Published on 29 May 2026

Finerenone combined with guideline-directed medical therapy in patients with post-myocardial infarction heart failure: a real-world study

in Cardiovascular and Smooth Muscle Pharmacology

Di Zhao
Jingsong Xia
Zhenhua Yang
Yonghong Yong
Liansheng Wang
Jiabao Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1754115

655 views

Original Research

Published on 29 May 2026

Mechanistic prediction of angelicae pubescentis radix in preventing arrhythmia via modulation of calcium channel targets: an integrated network pharmacology and target enrichment analysis

in Cardiovascular and Smooth Muscle Pharmacology

Duo Luo
Liang Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1778679

463 views

Review

Published on 28 May 2026

Therapeutic potential of growth hormone-releasing hormone analogues in cardiovascular and cerebrovascular diseases: mechanisms and preclinical evidence

in Cardiovascular and Smooth Muscle Pharmacology

Hao-Lin Ren
Yuliang Zhang
Kefan Yang
Lu Zhang
Yueyang Liu
Ming-Sheng Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1847309

654 views

Original Research

Accepted on 27 May 2026

Gastrodin alleviates cardiomyocyte senescence by regulating autophagy through the AMPK/mTOR/4EBP1 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Mingyue Yao
Simin Zhang
Yan Wu
Yunqian Huang
Yao Song
Lei Wang
Shan Li
Longhao Jia
Baihui Yao
Li Bo

Frontiers in Pharmacology

234 views

Original Research

Accepted on 26 May 2026

Gut Microbiota-Derived Butyrate Contributes to Baicalin-Induced Attenuation of Hypertensive Vascular Remodeling via Adventitial Immunity

in Cardiovascular and Smooth Muscle Pharmacology

Qiurong Xie
Yanyan Yang
Jiekun Lin
Yuehong Ye
Jiyan Lin
Meizhu Wu
Zhi Guo
Aling Shen
Weiquan Zeng
Jun Peng

Frontiers in Pharmacology

240 views

Original Research

Published on 26 May 2026

Platycodin D alleviates cardiac hypertrophy in the treatment of heart failure by inhibiting p53-dependent BCL-2/Bax/caspase-3 signaling pathway

in Cardiovascular and Smooth Muscle Pharmacology

Yingrui Li
Heng Li
Bin Liu
Yu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1832803

678 views

Original Research

Published on 26 May 2026

Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB1 receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat model

in Cardiovascular and Smooth Muscle Pharmacology

Piotr Ryszkiewicz
Patryk Remiszewski
Anna Pędzińska-Betiuk
Krzysztof Mińczuk
Marta Baranowska-Kuczko
Jolanta Weresa
Barbara Malinowska

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1831802

697 views

Original Research

Accepted on 25 May 2026

Comparative cardiovascular outcomes of renin–angiotensin system inhibitors in patients receiving maintenance hemodialysis: a large real-world cohort study

in Cardiovascular and Smooth Muscle Pharmacology

Jheng-Yan Wu
Keng-Wei Lee
Sheng-Chi Huang
Hsuan-Yuan Chang
Yu Min Lin

Frontiers in Pharmacology

260 views

1,502 articles

articles

Editorial: Innovative approaches and molecular mechanisms in cardiovascular pharmacology

Activation of BK channels ameliorates cardiac injury Via NFκB-NLRP3 signaling in angiotensin II-induced hypertension mouse model

Investigation of Potential Sex-Based Differences in Trastuzumab-Induced Chronic Cardiotoxicity in a Rat Model

Ferroptosis Regulation in Doxorubicin-Induced Cardiotoxicity: Multi-Mechanism Interventions and Translational Strategies

Curcumin protects high glucose-induced diabetic myocardial injury by regulating Nrf2 and PI3K/AKT pathways

From heart to brain: a Case Report of individualized antithrombotic management for left ventricular thrombus and stroke in a young patient with acute myocardial infarction

TRAF6 promotes pulmonary hypertension by enhancing K63-linked ubiquitination and activation of STAT3

Long-term efficacy and safety of solifenacin, mirabegron, and their combination for overactive bladder: a systematic review

Real-world bleeding risk and molecular interaction profiles of direct oral anticoagulants: a comparative study integrating clinical outcomes and in silico docking

A comprehensive review of ischemic heart disease: pathophysiology, current treatments, natural products-based therapies, and nanotherapeutics

Direct NLRP3 Inflammasome Inhibitors for Cardiovascular Therapeutics: A Comparative Review of Synthetic and Natural Candidates

CCR2⁺ Macrophages Are Required for Exercise-Induced Cardiac Remodeling

PCSK9 inhibition alleviates sepsis-induced myocardial dysfunction by facilitating PINK1/Parkin-associated mitophagy

Bisphenols-enhanced platelet aggregation via TP, P2Y12, PAR1 and PAR4 Receptors: A Thrombotic Legacy in a Plastic-Ubiquitous World

Differential Recovery of Ventricular Repolarization and Hemodynamics Following Bupivacaine and Ropivacaine Intoxication: The Impact of Lipophilicity on Lipid Emulsion Efficacy

Icariin attenuates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome through SIRT3-mediated TFAM deacetylation

Finerenone combined with guideline-directed medical therapy in patients with post-myocardial infarction heart failure: a real-world study

Mechanistic prediction of angelicae pubescentis radix in preventing arrhythmia via modulation of calcium channel targets: an integrated network pharmacology and target enrichment analysis

Therapeutic potential of growth hormone-releasing hormone analogues in cardiovascular and cerebrovascular diseases: mechanisms and preclinical evidence

Gastrodin alleviates cardiomyocyte senescence by regulating autophagy through the AMPK/mTOR/4EBP1 pathway

Gut Microbiota-Derived Butyrate Contributes to Baicalin-Induced Attenuation of Hypertensive Vascular Remodeling via Adventitial Immunity

Platycodin D alleviates cardiac hypertrophy in the treatment of heart failure by inhibiting p53-dependent BCL-2/Bax/caspase-3 signaling pathway

Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB1 receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat model

Comparative cardiovascular outcomes of renin–angiotensin system inhibitors in patients receiving maintenance hemodialysis: a large real-world cohort study