Frontiers in Pharmacology | Drugs Outcomes Research and Policies

Systematic Review

Published on 04 Dec 2025

Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

in Drugs Outcomes Research and Policies

Renshu Zhang
Rui Wang
Yun Li
Wenqi Tian
Dandan Niu
Wencong Cheng
Xiaofang Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708316

305 views

Policy Brief

Accepted on 02 Dec 2025

Designing Integrated Early-Phase Protocols to Reduce Substantial Modifications, Including Considerations for Patient Cohorts – A Multi-Stakeholder Consensus View for a Practical Approach in Germany

in Drugs Outcomes Research and Policies

Robert Schultz-Heienbrok
Sybille Baumann
Ruwen Böhm
Andreas Bonertz
Kerstin Breithaupt-Grögler
Uta Buckpesch-Heberer
Martin Coenen
Katharina Erb-Zohar
Nadja Faisst
Guido Grass

Frontiers in Pharmacology

Original Research

Accepted on 02 Dec 2025

Challenges of Benzodiazepine Deprescribing in Elderly Patients Attending Primary Health Care

in Drugs Outcomes Research and Policies

Marlon Silva Tinoco
Silvio José Elisei Carvalho Júnior
Aline Istefane de Camargos Ramos
Luciana Soares Rodrigues
Mariana Linhares Pereira
Andre Oliveira Baldoni

Frontiers in Pharmacology

Original Research

Published on 02 Dec 2025

Navigating barriers to real-world evidence utilization for drug regulatory affairs and market access in Saudi Arabia

in Drugs Outcomes Research and Policies

Hatouf H. Sukkarieh
Nourah Al Fayez
Hussain Abdulrahman Al-Omar
Nura O. Azmi
Bushra Syed
Raed A. Albar
Nawaf Al Bali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712147

539 views

Clinical Trial

Published on 01 Dec 2025

The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery

in Drugs Outcomes Research and Policies

Min Shi
Tong Wang
Weiwei Wang
Jiafeng Wang
Lulu Li
Lulong Bo
Xiaolin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1728802

306 views

Original Research

Published on 01 Dec 2025

A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies

in Drugs Outcomes Research and Policies

Ziyad S. Almalki
Renad M. Alshammari
Nadia A. Dahduli
Mouaddh Abdulmalik Nagi
Syeda Juweria
Moayad M. Alhamdani
Yazan M. Alzahrani
Saja H. Almazrou
Nehad Jaser Ahmed
Abdullah K. Alahmari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695961

430 views

Original Research

Published on 01 Dec 2025

An intelligent framework for dynamic modeling of therapeutic response using clinical compliance data

in Drugs Outcomes Research and Policies

Xinyi Wang
Haoran Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631599

532 views

Original Research

Published on 01 Dec 2025

Investigating the pathways of medication adherence in renal transplant recipients based on the COM-B model: the parallel mediating effects of beliefs and emotion regulation efficacy

in Drugs Outcomes Research and Policies

Lili Zhou
Ke Cheng
Linbin Chen
San Han
Jingjing Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702618

210 views

Original Research

Accepted on 30 Nov 2025

Rapid health technology assessment of six non-ergot dopamine-receptor agonists for the treatment of early Parkinson's disease

in Drugs Outcomes Research and Policies

Jieqiong Lv
Hongbo Fu
Yanqiong Zhou
Wenwei Li
Zhang Jiaxin
Zhihua Zhou
Sha Lai

Frontiers in Pharmacology

Original Research

Published on 28 Nov 2025

Cost-effectiveness analysis of eight first-line treatments for metastatic hormone-sensitive prostate cancer in China

in Drugs Outcomes Research and Policies

Zhou Han
Youli Xi
Jian Hu
Ye Wang
Huanyu Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684966

442 views

Original Research

Accepted on 27 Nov 2025

Real-World Clinical Outcomes of EKOS Catheter-Directed Thrombolysis versus Systemic Alteplase in Acute Pulmonary Embolism: A Retrospective Cohort Study

in Drugs Outcomes Research and Policies

Tarek Mahmoud Senosy
Eman Fathi Abd Razik
Tarek Khairy Mosa
Ahmed Mahmoud Ali
Ahmed Ibrahim
Asmaa Elsayed
Engy Wahsh

Frontiers in Pharmacology

Opinion

Published on 27 Nov 2025

Breaking barriers: how generic drugs democratize mental health

in Drugs Outcomes Research and Policies

Gilberto Uriel Rosas-Sánchez
Marisol Mercado-Serna
Rafael Fernández-Demeneghi
María Isabel Pérez-Vega
Cesar Soria-Fregozo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733732

360 views

Original Research

Accepted on 26 Nov 2025

Cost-effectiveness analysis of baloxavir marboxil versus oseltamivir for seasonal influenza treatment in China

in Drugs Outcomes Research and Policies

Fangyu Zheng
Yuekun Tang
Hongli Jiang

Frontiers in Pharmacology

132 views

Editorial

Published on 26 Nov 2025

Editorial: Mathematical modeling of medication nonadherence

in Drugs Outcomes Research and Policies

Sean D. Lawley
Teresa B. Gibson
Zheng Jiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1741041

498 views

Original Research

Published on 26 Nov 2025

Cost-effectiveness analysis of first-line versus second-line use of CDK4/6 inhibitors combined with endocrine therapy in advanced HR+/HER2- breast cancer in China: based on the SONIA trial

in Drugs Outcomes Research and Policies

Xiaohu Jin
Zhifeng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700291

343 views

Original Research

Accepted on 25 Nov 2025

Association between vancomycin therapeutic drug monitoring and improved clinical outcomes in critically ill patients receiving renal replacement therapy: A retrospective cohort study

in Drugs Outcomes Research and Policies

Huaidong Peng
Xiaomei Tang
Lijin Chen
Qilin Yang
Jinliang Cai
Tingting Xie
Dan Xu

Frontiers in Pharmacology

106 views