Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 15 May 2025

Nafamostat mesylate augments survival in rats afflicted by exertional heat stroke

in Experimental Pharmacology and Drug Discovery

Qingwei Lin
Zhuqing Luo
Longping He
Lincui Zhong
Qingbo Zeng
Ye Zhou
Qi Chen
Xingping Deng
Xiaomin Song
Qing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559181

510 views

Review

Published on 14 May 2025

Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights

in Experimental Pharmacology and Drug Discovery

Meiting Ma
Zhengqi Chu
Hongyu Quan
Hanxu Li
Yuran Zhou
Yanhong Han
Kefeng Li
Wenjun Pan
De-Yun Wang
Yan Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524654

988 views

Mini Review

Published on 14 May 2025

Sphingosine 1-phosphate receptor 1 modulators exert neuroprotective effects in central nervous system disorders

in Experimental Pharmacology and Drug Discovery

Shouming Chen
Lan Wu
Bingchen Lang
Guoyan Zhao
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1516991

705 views

Original Research

Published on 14 May 2025

Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats

in Experimental Pharmacology and Drug Discovery

Hancheng Li
Yongen Peng
Yangkai Wu
Yiling Chen
Jieyu Li
Yunbing He
Hongwu Wang
Chaohua Luo
Zhixian Mo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541442

590 views

Review

Published on 14 May 2025

Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy

in Experimental Pharmacology and Drug Discovery

Pratibha Pandey
Sorabh Lakhanpal
Ashok Kumar Bishoyi
S. Renuka Jyothi
Swati Mishra
Meenakshi Verma
Ajay Singh
Mir Waqas Alam
Safia Obaidur Rab
Mohd Saeed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600347

926 views

Original Research

Published on 14 May 2025

Bioactive fraction isolated from Curcuma angustifolia rhizome exerts anti-diabetic effects in vitro, in silico and in vivo by regulating AMPK/PKA signaling pathway

in Experimental Pharmacology and Drug Discovery

P. Kavya
M. Gayathri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570533

791 views

Original Research

Published on 14 May 2025

Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity

in Experimental Pharmacology and Drug Discovery

Yu Liao
Mingchao Wang
Fuli Qin
Taotao Liu
Jiemei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571480

765 views

Original Research

Accepted on 13 May 2025

Design and Screening of Novel 1,2,4-Triazole-3-thione Derivatives as DCN1 Inhibitors for Anticardiac Fibrosis Based on 3D-QSAR Modeling and Molecular Dynamics

in Experimental Pharmacology and Drug Discovery

Wengong Bian
YaXin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590711

150 views

Original Research

Accepted on 13 May 2025

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota

in Experimental Pharmacology and Drug Discovery

Lixuan Yang
Yutian Ao
Yannan Li
Baoan Dai
Junnan Li
Wenzhe Duan
Kaiqiang Dong
Zhenyun Han
Rongjuan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510250

Original Research

Published on 13 May 2025

Probiotic biofilm modified bioceramics for bone defect healing via osteogenesis, angiogenesis, and immune modulation

in Experimental Pharmacology and Drug Discovery

Junwei Su
Huiyun Gu
Xiang Huang
Ying Yuan
Yunchang Zhao
Fan Yang
Yong Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588023

531 views

Original Research

Published on 13 May 2025

Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis

in Experimental Pharmacology and Drug Discovery

Zhimin Mao
Ping Chen
Qun Ji
Xiuling Zhao
Kun Zhong
Xuhui Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562852

428 views

Original Research

Accepted on 12 May 2025

MD-Syn: Synergistic drug combination prediction based on the multidimensional feature fusion method and attention mechanisms

in Experimental Pharmacology and Drug Discovery

XinXin Ge
Yi-Ting Lee
Shan-Ju Yeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564339

108 views

Review

Published on 12 May 2025

Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV

in Experimental Pharmacology and Drug Discovery

Zhongsong Zhang
Run Tan
Zuanyu Xiong
Yanyan Feng
Long Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562845

774 views

Original Research

Published on 12 May 2025

Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology

in Experimental Pharmacology and Drug Discovery

Jie Zou
Xia-Juan Xiao
Ping Zhang
Xing-Zi Huang
Jing Wang
Chun-Qin Tao
Xiao-Lan Ou
Gong Chen
Ting-Hao He
Long Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542851

621 views

Original Research

Published on 09 May 2025

Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis

in Experimental Pharmacology and Drug Discovery

Guangyun Luo
Xiangyi Kong
Fang Wang
Zhiming Wang
Zhuo Zhang
Huan Cui
Yiwen Zhang
Wen Huang
Xuesong Yang
Jianzhou Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585369

853 views

Original Research

Published on 09 May 2025

Target screening and optimization of candidate compounds for breast cancer treatment using bioinformatics and computational chemistry approaches

in Experimental Pharmacology and Drug Discovery

Jian Xu
Xue Li
Yiduo Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1467504

673 views