Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 27 Jun 2025

Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation

in Experimental Pharmacology and Drug Discovery

Puneet Kumar
Tusharika Kotra
Waseem I. Lone
Yassir Arfath
Harshita Tiwari
Ashutosh Kumar Shukla
Zabeer Ahmed
Sheikh Rayees
Jasha Momo H. Anal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528235

926 views

Original Research

Published on 27 Jun 2025

Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches

in Experimental Pharmacology and Drug Discovery

Vid Ravnik
Marko Jukič
Veronika Furlan
Uroš Maver
Jan Rožanc
Urban Bren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611461

1,054 views

Original Research

Published on 27 Jun 2025

Design and screening of novel 1,2,4-Triazole-3-thione derivatives as DCN1 inhibitors for anticardiac fibrosis based on 3D-QSAR modeling and molecular dynamics

in Experimental Pharmacology and Drug Discovery

Wengong Bian
Yaxin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590711

615 views

Original Research

Published on 26 Jun 2025

i-DENV: development of QSAR based regression models for predicting inhibitors targeting non-structural (NS) proteins of dengue virus

in Experimental Pharmacology and Drug Discovery

Sakshi Gautam
Anamika Thakur
Manoj Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605722

951 views

Review

Published on 26 Jun 2025

Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry

in Experimental Pharmacology and Drug Discovery

Wenjie Jiang
Jing Zeng
Li Guo
Jianyou Shi
Yang Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571452

728 views

Original Research

Published on 26 Jun 2025

Hydrogen sulfide alleviates high-salt-stimulated myocardial fibrosis through inhibiting hypoxia-inducible factor-1α

in Experimental Pharmacology and Drug Discovery

Qian Peng
Pan Huang
Boyang Lv
Chaoshu Tang
Hongfang Jin
Yaqian Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502269

710 views

Editorial

Published on 26 Jun 2025

Editorial: Application of PKPD modeling in drug discovery and development

in Experimental Pharmacology and Drug Discovery

Hong-Can Ren
Xiao Zhu
Kun Hao
Si-Yuan Le

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614689

878 views

Original Research

Published on 25 Jun 2025

Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation

in Experimental Pharmacology and Drug Discovery

Xiao Cheng
Sixuan Zhao
Yucai Chen
Jiawei Wang
Furong Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586173

593 views

Systematic Review

Published on 25 Jun 2025

The role of synovial mesenchymal stem cell-derived exosomes in cartilage repair: a systematic review

in Experimental Pharmacology and Drug Discovery

Jiemao Su
Yansong Qi
Lin Niu
Yongxiang Wang
Baogang Wei
Bingxian Ma
Keyu Kong
Zanjing Zhai
Yongsheng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617874

861 views

Original Research

Published on 25 Jun 2025

KU124 (9,10,10-trioxo-N-(2-phenylphenyl)thioxanthene-3-carboxamide) as a novel inhibitor of TASK-1

in Experimental Pharmacology and Drug Discovery

Ana Dumani
Annette Jacob
Diego Chavez
Abena Amankwaa
Ramish Zahed
Martha Julemis
Hinaben Patel
Joana Lopez
Steven Almazan
Patrick Martins

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577171

1,786 views

Original Research

Accepted on 24 Jun 2025

Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models

in Experimental Pharmacology and Drug Discovery

Leonard Burg
Heeyong Yoon
Min Peng
Peter Germano
Emily Reesey Gretzmacher
Vernon Anderson
Eiko Nakamaru-Ogiso
Marni Falk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588426

185 views

Original Research

Accepted on 24 Jun 2025

Exploring the mechanism of action of Sophora moorcroftiana seeds on Pneumonia based on Network pharmacology, Molecular docking, and experimental verification

in Experimental Pharmacology and Drug Discovery

Yuzhang Xu
Fanlin Wu
Heng BAI
Zhenshuai Wu
Cidan Laba
Cuomu Wujin
Peng Ji
Yongli Hua
Xiuqin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544550

182 views

Review

Published on 24 Jun 2025

Eucommia ulmoides Oliv. and its bioactive compounds: therapeutic potential in bone diseases

in Experimental Pharmacology and Drug Discovery

Cai Huang
Huan Jin
Yan Zhang
Di Wang
Ziyi He
Bo Shuai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601537

978 views

Original Research

Accepted on 23 Jun 2025

Peptide-mimetics derived from leucyl-tRNA synthetase are potential agents for the therapy of mt-tRNA related diseases

in Experimental Pharmacology and Drug Discovery

Annalinda Pisano
Sara Belloli
Maria Gemma Pignataro
Paolo Rainone
Silvia Valtorta
Angela Coliva
Luciana Mosca
Patrizio Di Micco
Rosa Maria Moresco
Giulia D'Amati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607343

192 views

Review

Published on 23 Jun 2025

Opening new frontiers with catalytic nucleic acids in miRNA inhibition

in Experimental Pharmacology and Drug Discovery

Olga Patutina
Svetlana Miroshnichenko
Daria Chiglintseva
Marina Zenkova

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604711

915 views

Review

Published on 23 Jun 2025

Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains

in Experimental Pharmacology and Drug Discovery

Katherine E. Larrimore
Yevgeniy V. Serebrenik

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593844

933 views