Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Clinical Trial

Published on 29 Oct 2025

Atorvastatin as an immunomodulatory adjunct in ulcerative colitis, beyond lipid lowering to inflammation control: a randomized controlled pilot study

in Gastrointestinal and Hepatic Pharmacology

Mohannad O. Khrieba
Furqan M. Abdulelah
Nada A. Alsaleh
Hayam Ali AlRasheed
Tarek I. Ahmed
Azza El-Sayed Mansy
Manal A. Hamouda
Eslam Habba
Nora Elshorbagi
Ahmed G. Abd Elhameed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690513

272 views

Systematic Review

Published on 28 Oct 2025

The impact of proton pump inhibitor exposure on pneumonia: an updated meta-analysis based on randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Zhujun Wu
Yixuan Wu
Zhiyi Xiang
Yi Qiu
Wangyi Xuan
Shengying Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713256

370 views

Original Research

Accepted on 27 Oct 2025

Temporal Metabolic Reprogramming in DSS-Induced Colitis Identifies Purine Metabolism and Trigonelline as Novel Therapeutic Targets

in Gastrointestinal and Hepatic Pharmacology

Qi Zhang
JIANGUO WANG
Long Zhang
Kangjie Song
Xiaoming Sun
Ya-Ming Zhang
Fubao Liu

Frontiers in Pharmacology

Original Research

Accepted on 27 Oct 2025

Cistanche deserticola-Derived Exosome-Like Nanovesicles Target the Microbiota-GABA Signaling Axis to Ameliorate Loperamide-Induced Constipation

in Gastrointestinal and Hepatic Pharmacology

Xiaoyu Zhang
Keqiu Yan
Xinkun Bao
Dequn Yang
Xiaoyin Chen
Wenjie Xiao
Jinbo Zhou
Yifan Cai
Hao Wang
Guangjun Sun

Frontiers in Pharmacology

115 views

Original Research

Published on 27 Oct 2025

Effects of different opioids on the contractile tension of isolated rat intestinal smooth muscle

in Gastrointestinal and Hepatic Pharmacology

Chen Yang
Jianying Hu
Yan Cheng
Shen Sun
Shaoqiang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617936

257 views

Clinical Trial

Published on 27 Oct 2025

Determination of the effective dose of oliceridine combined with propofol using the modified Dixon’s up-and-down method in painless gastroscopy

in Gastrointestinal and Hepatic Pharmacology

Jinfeng Cao
Xiaoyu Gu
Xinyang Zhang
Yao Cheng
Liuqin Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620158

262 views

Original Research

Published on 24 Oct 2025

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

in Gastrointestinal and Hepatic Pharmacology

Qi Yu
Yiyu Cheng
Huan Wang
Yidong Chen
Fang Liu
Xiaopeng Zhang
Xiaoyu Fu
Jiamin Li
Junrong Li
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621795

444 views

Brief Research Report

Accepted on 23 Oct 2025

Salivary oxidative stress persists in Inflammatory Bowel Disease regardless of biological treatment response

in Gastrointestinal and Hepatic Pharmacology

Elisabetta Bigagli
Tommaso Innocenti
Gabriele Dragoni
Francesco Pindozzi
Andrea Galli
Maura Lodovici
Cristina Luceri

Frontiers in Pharmacology

318 views

Mini Review

Accepted on 21 Oct 2025

Immunometabolic Integration in Therapeutic Strategies for Managing MASLD

in Gastrointestinal and Hepatic Pharmacology

Sergio González Serrano
Alina-Iuliana Onoiu
Jordi Camps
Jorge Joven

Frontiers in Pharmacology

334 views

Original Research

Published on 20 Oct 2025

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration

in Gastrointestinal and Hepatic Pharmacology

Liya Liu
Peiyao Li
Youqin Chen
Guangqing Yang
Ying Cheng
Sijia Liu
Xinran Zhang
Yulun Wu
Qihong Liu
Peilin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684442

1,066 views

Original Research

Published on 20 Oct 2025

The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study

in Gastrointestinal and Hepatic Pharmacology

Boxian Chen
Yuping Yang
Mouji Liang
Yanqi Kou
Ruyin Ye
Liping Zhan
Yujie Huang
Qing Zhang
Haoyuan Huang
Jieming Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551495

978 views

Perspective

Accepted on 17 Oct 2025

Not Quite a Cure Yet: Unlocking the Unfulfilled Promise of Live Biotherapeutics for Disease Treatment

in Gastrointestinal and Hepatic Pharmacology

Andrea Verdugo-Meza
Han M. Chiang
Emeran A Mayer
Deanna L Gibson

Frontiers in Pharmacology

137 views

Original Research

Accepted on 15 Oct 2025

Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

in Gastrointestinal and Hepatic Pharmacology

Ana Teofilović
Milos Vrataric
Biljana Bursać
Ljupka Gligorovska
Danijela Vojnović Milutinović
Nemanja Stanisavljević
Ivana Strahinic
Danijela M Mišić
Filip Nikolić
Bojan Pavlović

Frontiers in Pharmacology

154 views

Original Research

Published on 15 Oct 2025

Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Wenwen Li
Yingying Liang
Guangcai Li
Dandan Yang
Xiaoqian Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688544

1,268 views

Mini Review

Published on 13 Oct 2025

The role of cuproptosis in the occurrence and development of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Ling Lu
Wenhui Yang
Yuning Gu
Longtao Jin
Zhaofeng Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664200

527 views

Original Research

Published on 09 Oct 2025

Identification of galangin as a therapeutic candidate for primary biliary cholangitis via systematic druggable genome-wide Mendelian randomization analysis and experimental validation

in Gastrointestinal and Hepatic Pharmacology

Weirui Ren
Chuang Zhang
Hanyan Wang
Hongzhao Song
Xuejuan Zhu
Zhijun Zhang
Suxian Zhao
Junmin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674693

1,366 views