Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Systematic Review

Published on 27 Nov 2025

Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yan Pan
Youting Xu
Ting Shui
Jiao Hong
Xuan Lu
Huilin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707784

227 views

Review

Accepted on 26 Nov 2025

The pharmacological effects and therapeutic potential of flavonoids in digestive diseases

in Gastrointestinal and Hepatic Pharmacology

Junkang Xu
Mengxuan Zhu
Xu Chen
Wenjing Chen
Jingyi Zhang
Cuizhe Liu
Lin Zhang

Frontiers in Pharmacology

Systematic Review

Accepted on 26 Nov 2025

From Mechanisms to Anti‑fibrotic Drugs in Hepatic Stellate Cell Research: A Global Bibliometric Analysis with Patent and Clinical Perspectives (2000–2025)

in Gastrointestinal and Hepatic Pharmacology

Xiao-wen Mao
Peng Chen
Paridan Wabul
Yi Liu
Yuan Zhao
Siwei Zhang
Na Guan
Bin Li

Frontiers in Pharmacology

Systematic Review

Accepted on 26 Nov 2025

A Network Meta-analysis of First-line Treatment Options for Patients with Child-Pugh Class B Functional Hepatocellular Carcinoma: Comparison of Efficacy and Safety

in Gastrointestinal and Hepatic Pharmacology

Yu-Xuan Zhang
Junyi Wu
Jia-Yi Wu
Zhen-Xin Zeng
Rong-Jian Pan
Xiang-Ye Ou
Yi-Nan Li
Maolin Yan

Frontiers in Pharmacology

Review

Accepted on 25 Nov 2025

Dietary polyphenols maintain human health through modulation of gut microbiota

in Gastrointestinal and Hepatic Pharmacology

Mithun Rudrapal
André Mauricio De Oliveira
Ravi Pratap Singh

Frontiers in Pharmacology

127 views

Original Research

Published on 25 Nov 2025

Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway

in Gastrointestinal and Hepatic Pharmacology

Junming Xu
Xiaopu Sang
Yongfei He
Jie Ke
Jiasen Xu
Tanbin Liu
Jicai Wang
Hang Zhai
Xiaoni Chen
Xianjie Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730255

307 views

Original Research

Published on 25 Nov 2025

SLC11A1 protein as a key regulator of iron metabolism, ferroptosis mediator, and putative therapeutic target in nonalcoholic fatty liver disease: an integrated bioinformatics analysis

in Gastrointestinal and Hepatic Pharmacology

Yang Wang
Bugao Zhou
Shanshan Li
Linxin Zheng
Xiongfeng Huang
Huiyu Wang
Sili Li
Yuhan Lin
Yanhe Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715699

252 views

Original Research

Accepted on 24 Nov 2025

Fraxin Modulates Lipid Metabolism as well as Gut Flora to Avert NAFLD

in Gastrointestinal and Hepatic Pharmacology

Jing Yang
huicong Dong
xuanci Guo
cao Li
huanhuan zhang
yongze guo

Frontiers in Pharmacology

126 views

Original Research

Published on 24 Nov 2025

Temporal metabolic reprogramming in DSS-induced colitis identifies purine metabolism and trigonelline as novel therapeutic targets

in Gastrointestinal and Hepatic Pharmacology

Qi Zhang
Jianguo Wang
Long Zhang
Kangjie Song
Xiaoming Sun
Yaming Zhang
Fubao Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691978

278 views

Original Research

Accepted on 21 Nov 2025

Machine learning-assisted analysis of serum metabolomics for Identifying Biomarkers in Intrinsic and Idiosyncratic Drug-Induced Liver Injury

in Gastrointestinal and Hepatic Pharmacology

Xianni Wei
Jinbao Wei
Yuhong Huang
Siheng Lian

Frontiers in Pharmacology

140 views

Systematic Review

Accepted on 20 Nov 2025

Microplastics in Focus: A Silent Disruptor of Liver Health-A Systematic Review

in Gastrointestinal and Hepatic Pharmacology

Zahra Beyzaei
Bita Geramizadeh
Zahra Bagheri
Sara Karimzadeh
Ralf Weiskirchen

Frontiers in Pharmacology

141 views

Review

Published on 20 Nov 2025

Research progress on the use of polyphenols in the treatment of Crohn’s disease

in Gastrointestinal and Hepatic Pharmacology

Xianmei Zhong
Qian Dai
Jing Li
Jie Yang
Xi Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704901

377 views

Systematic Review

Published on 20 Nov 2025

Therapeutic effect and safety of Wei-Fu-Chun in the treatment of chronic atrophic gastritis: a network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yunbo Wu
Ling Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693427

329 views

Systematic Review

Published on 19 Nov 2025

Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Mengdan Shen
Shan Lu
Zihao Xu
Feifei Zhou
Li-Ting Sheng
Qiang Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645387

355 views

Original Research

Published on 18 Nov 2025

Glial cell line-derived neurotrophic factor inhibits mast-cell-like RBL-2H3 cells activation via Ca2+-mediated degranulation and Ca2+/CaMKⅡ/JNK pathway

in Gastrointestinal and Hepatic Pharmacology

Wei Huang
Li Zeng
Li Zhang
Xinxing Zhang
Qin Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697815

421 views

Systematic Review

Published on 14 Nov 2025

Different nucleos(t)ide analogs in resected hepatitis B virus-associated hepatocellular carcinoma: a systematic review

in Gastrointestinal and Hepatic Pharmacology

Hongquan Qiu
Yu Zhang
Fengxia Xu
Songhui Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1647888

416 views