Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 28 Apr 2025

Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia

in Neuropharmacology

Mohammad Hleihil
Musadiq A. Bhat
Thomas Grampp
Dietmar Benke

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576884

323 views

Mini Review

Published on 28 Apr 2025

The prospective approach for aptamers applied in the treatment and molecular diagnostics of ischemic stroke

in Neuropharmacology

Wenfeng Li
Junyi Wu
Zijian Hu
Jixuan Zhang
Guangming Ye
Fengling Luo
Zhikun Zeng
Yi Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553337

279 views

Original Research

Published on 28 Apr 2025

Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF

in Neuropharmacology

Jiu-Jian Zhou
Jie Zhao
Shang-Yan Gao
Yuan-yuan Gao
Cheng Chen
Yi Ding
Zhong-hua Wu
Pu-Jian Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587399

252 views

Mini Review

Published on 28 Apr 2025

The role of glutamate dehydrogenase in the ageing brain

in Neuropharmacology

Tao Zhou
Haichuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586655

176 views

Review

Published on 28 Apr 2025

Current insights and prospects for the pathogenesis and treatment of clinical manifestations associated with Down syndrome through neurotransmitter, inflammatory, and oxidative stress pathways

in Neuropharmacology

Fawaz Alasmari
Ashfaq Ahmad
Sary Alsanea
Alaa M. Hammad
Walid Al-Qerem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592277

267 views

Original Research

Accepted on 25 Apr 2025

Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: An integrated approach for therapeutic development against major depressive disorder

in Neuropharmacology

Abdelbaset Mohamed Elasbali
Ahmed S Ali
Taj Mohammad
Mohd Adnan
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599297

124 views

Editorial

Published on 25 Apr 2025

Editorial: Interplay between chronic pain and affective-cognitive alterations: shared neural mechanisms, circuits, and treatment

in Neuropharmacology

Luca Posa
Danilo de Gregorio
Serena Boccella
Kelly Smart

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605670

450 views

Systematic Review

Published on 25 Apr 2025

Effectiveness and safety of single anti-seizure medication as adjunctive therapy for drug-resistant focal epilepsy based on network meta-analysis

in Neuropharmacology

Nian-Jia Deng
Xin-Yi Li
Zhi-Xin Zhang
Chen-Yang Xian-Yu
Yu-Ting Tao
Yu-Tong Ma
Hui-Jun Li
Teng-Yu Gao
Xin Liu
Jie Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500475

433 views

Original Research

Published on 25 Apr 2025

Suicidal thoughts and behaviors associated with fluoroquinolone antibiotics: a real-world pharmacovigilance analysis

in Neuropharmacology

Lijuan Yang
Congqin Chen
Lingqing Ding
Tingting Lu
Xiwen Li
Jie Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556159

334 views

Original Research

Published on 25 Apr 2025

In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy

in Neuropharmacology

Mansi Dahalia
Haya Majid
Mohd Junaid Khan
Akshat Rathi
Mohd Ashif Khan
Imran Ahmd Khan
Mohammed Samim
Sayeed Ur Rehman
Md Salik Noorani
Divya Vohora

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580943

669 views

Mini Review

Published on 25 Apr 2025

Trace amine-associated receptors as potential targets for the treatment of anxiety and depression

in Neuropharmacology

Zelong Li
Luoting Wan
Jing Dong
Jinquan Li
Jianfeng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1598048

371 views

Original Research

Published on 25 Apr 2025

Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

in Neuropharmacology

Hui Zhang
Can Zhu
Xingyu Zhou
Laifa Wang
Ling Deng
Binsheng He
Jianming Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581320

406 views

Original Research

Accepted on 24 Apr 2025

Protective effects of AER-271 in acute-phase radiation-induced brain injury in rats: reduction of brain edema, inflammation, apoptosis and maintenance of blood-brain barrier integrity

in Neuropharmacology

Yaozu Xiong
Yifei Wang
Mingyue Li
Changhua Yu
Yusuo Tong
Xiaoting Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534729

Review

Accepted on 24 Apr 2025

Microglial Dynamics and Emerging Therapeutic Strategies in CNS Homeostasis and Pathology

in Neuropharmacology

Jie Cao
Jianqing Yuan
Nanhai Liu
Kai Huang
Mingwei Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577809

Case Report

Accepted on 24 Apr 2025

Case report：Analysis of the efficacy and safety of anti-infectious treatment for brain abscess caused by oral anaerobes

in Neuropharmacology

Chunfang Tian
Jingxian Liu
Zhiyu Chen
Lixia Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1506879

Original Research

Published on 24 Apr 2025

Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

in Neuropharmacology

Yingni Sun
Guoliang Bai
Kangmin Yang
Yong Feng
Hongmei Sun
Li Xian
Hongwei Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554168

355 views