Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 20 Nov 2025

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

in Neuropharmacology

Karolina E. Kolaczynska
Daniel Trachsel
Marius C. Hoener
Matthias E. Liechti
Dino Luethi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703480

460 views

Original Research

Published on 19 Nov 2025

Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction

in Neuropharmacology

Yan Du
Qing Ma
Xingcui Gao
Hongliang Su
Keming Yun
Li Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698866

1,063 views

Original Research

Published on 19 Nov 2025

Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters

in Neuropharmacology

Oliver Kudlacek
Niklas Senning
Alexandra Karden
Iina Ludwig
Julia Bicher
Fatemeh Kooti
Marion Holy
Thomas Stockner
Anton Luf
Harald H. Sitte

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699035

1,000 views

Original Research

Published on 19 Nov 2025

Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters

in Neuropharmacology

Kathryn J. Laloli
Peggy Rentsch
Sandy Stayte
Bryce Vissel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682979

993 views

Original Research

Accepted on 18 Nov 2025

T817MA attenuates oxidative stress and ER stress via the HSP70-HSP90 pathway after brain ischemia in vitro and in vivo

in Neuropharmacology

Tao Wang
Ya-Juan Pan
Mei-Mei Zhang
Xuan Wang
Wei Li
Jian-Meng Lv

Frontiers in Pharmacology

Systematic Review

Accepted on 18 Nov 2025

Is tranexamic acid effective for all traumatic brain injury patients? A Severity Based Systematic Review and Meta-Analysis

in Neuropharmacology

Wentao Bian
Mengxia Qi
Lu Ding
Yixuan Lu
Kangling Yan
Ziqi Wang
Jiancheng Zhang
Ping Zhou

Frontiers in Pharmacology

Original Research

Accepted on 18 Nov 2025

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior

in Neuropharmacology

Francisco J Flores-Ramirez
Glenn Pascasio
Remi Martin-Fardon

Frontiers in Pharmacology

Review

Accepted on 17 Nov 2025

Targeting the P2X7 Receptor in Cerebrovascular Diseases: From Molecular Mechanisms to Preclinical Therapeutic Potential

in Neuropharmacology

Hu Ziyan
Xie Shu Jing
Cheng Chen
Zhihui Luo
Xiao Deng
Renjie Xiao

Frontiers in Pharmacology

Original Research

Published on 14 Nov 2025

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

in Neuropharmacology

Seo-Hyun Lim
Young-Suk Choi
Eosu Kim
Chul Hoon Kim
Ho-Taek Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629824

5,958 views

Review

Published on 13 Nov 2025

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693253

7,170 views

Original Research

Published on 13 Nov 2025

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

in Neuropharmacology

Celtia Domínguez-Fernández
Amit Kumar
Rajnish Kumar
Taher Darreh-Shori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694610

7,493 views

Original Research

Published on 12 Nov 2025

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

in Neuropharmacology

Ilya S. Zhukov
Inessa V. Karpova
Ramilya Z. Murtazina
Yazen Alnefeesi
Olga M. Korenkova
Ilia Yu. Tissen
Svetlana A. Palchikova
Lydia A. Tokareva
Sarng S. Pyurveev
Petr D. Shabanov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684029

8,470 views

Original Research

Published on 12 Nov 2025

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

in Neuropharmacology

Timotej Glavač
Maruša Barbo
Metka Ravnik-Glavač
Maja Zupančič
Vita Dolžan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675538

7,836 views

Review

Accepted on 11 Nov 2025

Signal transduction, Dimerization, and Therapeutic Targeting of Orexin and Receptor Systems

in Neuropharmacology

Shengnan Zhang
Peixiang Wang
Bingyuan Ji
Yuming Shao
Sen Hou
Jing Chen
Chunmei Wang

Frontiers in Pharmacology

122 views

Original Research

Accepted on 10 Nov 2025

ER Stress in D1-MSNs Mediates Cocaine-Induced Behavioral Plasticity via the ATF4–SPTLC1 Axis

in Neuropharmacology

Yue Zhao
Shu Li
Linhong Jiang
Ying Zhao
Weihong Kuang
Qingfan Wei
Yuanyi Zhou
Shuang Han
Liang Wang
Hongchun Li

Frontiers in Pharmacology

130 views

Original Research

Accepted on 10 Nov 2025

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

in Neuropharmacology

Mark K Greenwald
Catherine Demery
Tabitha E.H. Moses
Margit Burmeister

Frontiers in Pharmacology

168 views