Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 04 Jun 2025

Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study

in Pharmacogenetics and Pharmacogenomics

Sireen Abdul Rahim Shilbayeh
Naglaa F. Khedr
Mohammad A. Alshabeeb
Abdulmonem Ali Alsaleh
Abdalrhman Hamdan Alanizi
Omnia A. Abd El-Baset
Rehab H. Werida

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604473

438 views

Original Research

Published on 03 Jun 2025

Exosomal miR-24-3p mediates myoblast-macrophage crosstalk to promote abdominal muscle repair

in Pharmacogenetics and Pharmacogenomics

Yuchen Liu
Zhenyu Zou
Jinxin Cao
Tong Zhu
Yilin Zhu
Yingmo Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604776

313 views

Original Research

Accepted on 26 May 2025

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer

in Pharmacogenetics and Pharmacogenomics

Lin-Ting Zhang
Yuejia Zhou
Tiantian Wang
Boran Cheng
Zhigao Cai
Shubin Wang
Gangling Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541820

123 views

Brief Research Report

Published on 23 May 2025

Dynamic star allele definitions in Pharmacogenomics: impact on diplotype calls, Phenotype predictions and statin therapy recommendations

in Pharmacogenetics and Pharmacogenomics

Sven van der Maas
Simon Denil
Brigitte Maes
Gökhan Ertaylan
Pieter-Jan Volders

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584658

483 views

Brief Research Report

Published on 22 May 2025

Implementation and integration of a multidisciplinary pharmacogenomics service in an underserved integrated behavioral health clinic

in Pharmacogenetics and Pharmacogenomics

Bader M. Alghamdi
Sara Rogers
Susan Roberman
Meredith Williamson
Ladan Panahi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594032

535 views

Original Research

Published on 22 May 2025

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

in Pharmacogenetics and Pharmacogenomics

Qiang Liu
Huiguo Chen
Dongfang Tang
Huibiao Zhang
Shaogeng Chen
Yiran Meng
Boying Zheng
Fei Liu
Jing Zhou
Wen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562261

537 views

Case Report

Published on 21 May 2025

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

in Pharmacogenetics and Pharmacogenomics

Yan Zhan
Jin-Mao Liao
Ling Ye
Long Zhang
Zheng Zhang
Ji-Ye Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564124

471 views

Original Research

Published on 20 May 2025

ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma

in Pharmacogenetics and Pharmacogenomics

Fangfang Yang
Helei Hou
Guanqun Wang
Guangming Fu
Xingfa Huo
Xueqin Duan
Na Zhou
Xiaochun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582005

524 views

Systematic Review

Accepted on 14 May 2025

CYP2C19 Variability and Clinical Outcomes of Clopidogrel, Proton Pump Inhibitors, and Voriconazole in Southeast Asia: A Systematic Review and Meta-Analysis

in Pharmacogenetics and Pharmacogenomics

Harri Hardi
Agian Jeffilano Barinda
Liganda Endo Mahata
Zahra Fitrianti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572886

139 views

Original Research

Published on 13 May 2025

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients

in Pharmacogenetics and Pharmacogenomics

Lesly Yanira Xajil-Ramos
Jesús Alonso Gándara-Mireles
Rodrigo José Vargas Rosales
Oscar Kevin Sánchez García
Andrea Mariela Ruano Toledo
Amy Kateleen Aldana de la Cruz
Ismael Lares-Asseff
Leslie Patrón-Romero
Horacio Almanza-Reyes
Randall Lou-Meda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592134

1,004 views

Case Report

Published on 13 May 2025

Primary hyperoxaluria type I diagnosed after a kidney transplant presenting with subcutaneous calcification: a case report of sodium thiosulfate treatment

in Pharmacogenetics and Pharmacogenomics

Min Wu
Jing Lu
Yu-Jia Wang
Yong-Qi Li
Qing Wei
Yu-Xiang Gong
Ri-Ning Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485024

614 views

Original Research

Published on 01 May 2025

Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population

in Pharmacogenetics and Pharmacogenomics

Mohammad A. Alshabeeb
Deemah Alwadaani
Sireen A. R. Shilbayeh
Fatemah A. Alherz
Ali Alghubayshi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559399

2,001 views

Original Research

Published on 30 Apr 2025

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

in Pharmacogenetics and Pharmacogenomics

Salha Jokhab
Maha M. AlRasheed
Dana Bakheet
Abdulkareem AlMomen
Nouf AlAboud
Farhad Kamali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547142

780 views

Original Research

Published on 28 Apr 2025

Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients

in Pharmacogenetics and Pharmacogenomics

Ahmed Essam Abou Warda
Rylie M. Flohr
Rania M. Sarhan
Mohamed Nabil Salem
Heba F. Salem
Ayman N. Moharram
Abdullah S. Alanazi
Christelle Lteif
Brian E. Gawronski
Leanne Dumeny

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539870

1,251 views

Review

Published on 28 Apr 2025

Research progress on m6A and drug resistance in gastrointestinal tumors

in Pharmacogenetics and Pharmacogenomics

Ziyi Xu
Bo Sun
Weizheng Wang
Yitao Fan
Jingxiang Su
Jiachun Sun
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565738

798 views

Original Research

Published on 14 Apr 2025

Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

in Pharmacogenetics and Pharmacogenomics

Samantha Espinoza-Ferrao
Gabriela Echeverría-Garcés
Sebastián Rivera-Orellana
José Bueno-Miño
Emilia Castellanos-Molina
Melanie Benítez-Núñez
Andrés López-Cortés

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524623

1,232 views