Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Case Report

Accepted on 22 Jan 2026

Case Report: Severe SIADH and QTc Prolongation Induced by Escitalopram-Quetiapine interaction in a CYP2C19 Intermediate Metabolizer at Therapeutic Doses

in Pharmacogenetics and Pharmacogenomics

Zongchen Jiang
Xiaoyu Qu
Zimin Yan
Jungang Fang
Jin Lan
Xin Zhao
Wensheng Qi

Frontiers in Pharmacology

Review

Published on 22 Jan 2026

Addressing genetic diversity and health inequities: RELIVAF’s proposal for Latin American pharmacogenomic guidelines

in Pharmacogenetics and Pharmacogenomics

Luis A. Quiñones
Matías F. Martínez
Rodrigo Vargas
Leslie C. Cerpa
Andrés López-Cortés
Farith González-Martínez
Dora Fonseca
Jorge Duconge
Nelson M. Varela
Ismael Lares-Asseff

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1721828

329 views

Review

Accepted on 21 Jan 2026

Cellular Strategies for Repairing Trapped Protein-DNA Complexes

in Pharmacogenetics and Pharmacogenomics

Theodoros Rampias
Maria Sideridou
Doukissa Ioanna Machli
Dora Londra

Frontiers in Pharmacology

Original Research

Published on 21 Jan 2026

Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets

in Pharmacogenetics and Pharmacogenomics

Alexander Lachmann
Letizia Amadori
Paola Nicoletti
Heidi M. Crane
Chiara Giannarelli
Avi Ma’ayan
Inga Peter

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743543

270 views

Original Research

Published on 21 Jan 2026

The post-marketing safety of venlafaxine: a real-world two-decade pharmacovigilance study using the FAERS database

in Pharmacogenetics and Pharmacogenomics

Santosh Chokkakula
Hualiang Yang
Abeer A. Al-Masri
Yiquan Zhang
Bommireddy Naveen
Bing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1737113

330 views

Mini Review

Accepted on 20 Jan 2026

Pharmacogenomics of Risperidone in Autism Spectrum Disorder: A minireview

in Pharmacogenetics and Pharmacogenomics

Caroline Rafaelli de Lima Honório
Beatriz Gafanhão Bobadilha
Melina Pinheiro Conscetta
Felipe De Mello Silveira
Francisco Durigon
Aline Planello

Frontiers in Pharmacology

Original Research

Accepted on 19 Jan 2026

DPYD Genotyping in Patients Receiving Capecitabine: An exploratory analysis from the D-TORCH study

in Pharmacogenetics and Pharmacogenomics

Hemavathi Baskarane
Mohit Divakar
Akhil Santhosh
Kriti Pallavi
Vishakha Hooda
Vamsi Krishna Yenamandra
Saran Kumar
Vrajesh Shetty
Jahnavi Banotra
Ishaan Gupta

Frontiers in Pharmacology

126 views

Original Research

Published on 16 Jan 2026

Near, far, wherever you are: phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature

in Pharmacogenetics and Pharmacogenomics

Siobhan K. Lock
Djenifer B. Kappel
Jude Hutton
Emily Simmonds
Sophie E. Legge
Michael C. O'Donovan
Antonio F. Pardiñas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719761

394 views

Review

Published on 12 Jan 2026

Combining exercise and nanoparticle-based therapies: a review of physiological synergies and pharmacological potential

in Pharmacogenetics and Pharmacogenomics

Qinhai Wang
Jinxiang Sun
Zhanguo Su
Lijuan Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679552

343 views

Original Research

Accepted on 09 Jan 2026

NAPQI adducts in patients with selective hypersensitivity to acetaminophen

in Pharmacogenetics and Pharmacogenomics

Javier Gómez-Tabales
Jesús Miguel García-Menaya
Natalia Blanca Lopez
Maria de las Olas Cerezo-Arias
Antonio Silva-Rodríguez
Pedro Ayuso Parejo
Elena García-Martín
José A G Agúndez

Frontiers in Pharmacology

643 views

Mini Review

Published on 08 Jan 2026

ITGA4 genetic variants as a predictor of therapeutic responsivity to autoimmune diseases

in Pharmacogenetics and Pharmacogenomics

Matheus D. De Matos
Bárbara D. Guimenes
Giovanni K. Pavani
Gabriel Gripp Fernandes
Guilherme C. Montes
Fabrícia L. Fontes-Dantas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745315

463 views

Original Research

Accepted on 22 Dec 2025

Pharmacogenomic and in silico identification of isoform-selective AKT inhibitors from Pithecellobium dulce for precision cancer therapy

in Pharmacogenetics and Pharmacogenomics

Gnanaprakash Jeyaraj
Sathishkumar Kuppusamy
Dr.Santosh Chokkakula
Bader Almutairi
Bing Yang
Weimin Xie

Frontiers in Pharmacology

259 views

Mini Review

Published on 19 Dec 2025

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

in Pharmacogenetics and Pharmacogenomics

Adrian Szczepaniak
Kinga Jaskuła
Marta Zielińska
Jakub Godlewski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745087

1,185 views

Methods

Published on 02 Dec 2025

StarTRAC-CYP2D6: a method for CYP2D6 allele-specific copy number determination using digital PCR

in Pharmacogenetics and Pharmacogenomics

Wendy Y. Wang
Erin C. Boone
Lancy Lin
David Joun
Andrea Gaedigk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715830

1,289 views

Original Research

Published on 27 Nov 2025

Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis

in Pharmacogenetics and Pharmacogenomics

Zhi-Hu Zhao
Tao Ling
Songqing Ye
Wei Luo
Jian-Xiong Ma
Xinlong Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566890

1,228 views

Original Research

Published on 25 Nov 2025

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

in Pharmacogenetics and Pharmacogenomics

Santenna Chenchula
Atal Shubham
Rozatkar Abhijit
Tamonud Modak
Kohat Komal
Ratinder Jhaj
Singh Jitendra
Satyaprakash V.
Sadasivam Balakrishnan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697866

1,389 views

Original Research

Published on 21 Nov 2025

Assessing the views and opinions of psychiatric patients receiving genome-guided treatment within the scope of the PREPARE preemptive pharmacogenomics clinical study

in Pharmacogenetics and Pharmacogenomics

Margarita-Ioanna Koufaki
Maria-Theodora Pandi
Maria Skokou
Kariofyllis Karamperis
Konstantinos Vasileiou
Christina Mitropoulou
Marc S. Williams
George P. Patrinos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722339

796 views

Systematic Review

Published on 21 Nov 2025

Impact of CYP2C19 point-of-care testing on the clinical outcome in patients receiving personalized clopidogrel therapy: systemic review and meta-analysis

in Pharmacogenetics and Pharmacogenomics

Shaban Mohammed
Zainab Ali
Nermin Mohammed
Ayman El-Menyar
Jassim Al Suwaidi
Moza Al-Hail
Wadha Al-Muftah
Rania Abdel-Latif
Maw Shin Sim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621327

1,489 views

Original Research

Published on 19 Nov 2025

Pharmacogenetic associations of CYP2D6 and CYP2C19 variants with anticholinergic drug burden and hyposalivation

in Pharmacogenetics and Pharmacogenomics

Olga A. Korczeniewska
Scott Diehl
Abdul Basir Barmak
Tong Tong Wu
Eli Eliav
Szilvia Arany

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713345

685 views

Mini Review

Published on 13 Nov 2025

Inhibition of mesenchymal drift as a strategy for rejuvenation

in Pharmacogenetics and Pharmacogenomics

Lucas Paulo de Lima Camillo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715559

2,016 views

Original Research

Published on 30 Oct 2025

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

in Pharmacogenetics and Pharmacogenomics

Daniel Hain
Andria L. Del Tredici
Ryan B. Griggs
Rebecca Law
Brent Mabey
Holly L. Johnson
Katherine Johansen Taber
Kevin G. Lynch
Alexander Gutin
David W. Oslin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658616

2,466 views

Review

Published on 30 Oct 2025

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

in Pharmacogenetics and Pharmacogenomics

Haikuan Yu
Taojin Feng
Chengcheng Zhang
Zhouguang Jiao
Wenkai Fan
Rongxian Jiang
Dewen Kong
Fubing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699296

3,601 views

Original Research

Published on 09 Oct 2025

Patient and clinician perspectives on pharmacogenetic testing for antipsychotics

in Pharmacogenetics and Pharmacogenomics

Maria Richards-Brown
Yiran Wei
Rosemary Abidoph
Lauren Varney
Marius Cotic
Stephen Murtough
Daniele Panconesi
Daisy Mills
Alvin Richards-Belle
Noushin Saadullah Khani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689300

2,964 views

Original Research

Published on 08 Oct 2025

A digital twin of glimepiride for personalized and stratified diabetes treatment

in Pharmacogenetics and Pharmacogenomics

Michelle Elias
Matthias König

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686415

2,082 views
1 citation

650 articles

articles

Case Report: Severe SIADH and QTc Prolongation Induced by Escitalopram-Quetiapine interaction in a CYP2C19 Intermediate Metabolizer at Therapeutic Doses

Addressing genetic diversity and health inequities: RELIVAF’s proposal for Latin American pharmacogenomic guidelines

Cellular Strategies for Repairing Trapped Protein-DNA Complexes

Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets

The post-marketing safety of venlafaxine: a real-world two-decade pharmacovigilance study using the FAERS database

Pharmacogenomics of Risperidone in Autism Spectrum Disorder: A minireview

DPYD Genotyping in Patients Receiving Capecitabine: An exploratory analysis from the D-TORCH study

Near, far, wherever you are: phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature

Combining exercise and nanoparticle-based therapies: a review of physiological synergies and pharmacological potential

NAPQI adducts in patients with selective hypersensitivity to acetaminophen

ITGA4 genetic variants as a predictor of therapeutic responsivity to autoimmune diseases

Pharmacogenomic and in silico identification of isoform-selective AKT inhibitors from Pithecellobium dulce for precision cancer therapy

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

StarTRAC-CYP2D6: a method for CYP2D6 allele-specific copy number determination using digital PCR

Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

Assessing the views and opinions of psychiatric patients receiving genome-guided treatment within the scope of the PREPARE preemptive pharmacogenomics clinical study

Impact of CYP2C19 point-of-care testing on the clinical outcome in patients receiving personalized clopidogrel therapy: systemic review and meta-analysis

Pharmacogenetic associations of CYP2D6 and CYP2C19 variants with anticholinergic drug burden and hyposalivation

Inhibition of mesenchymal drift as a strategy for rejuvenation

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Patient and clinician perspectives on pharmacogenetic testing for antipsychotics

A digital twin of glimepiride for personalized and stratified diabetes treatment