Frontiers in Pharmacology | Pharmacology of Ion Channels and Channelopathies

Original Research

Accepted on 08 Sep 2025

Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop

in Pharmacology of Ion Channels and Channelopathies

Irina Yurievna Petrushanko
Denis Lisitskii
Filipp A. Filonov
Olga G. Leonova
Vladimir Alexandrovich Mitkevich
Maria Strelkova
Alexander Alexander Makarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665715

733 views

Original Research

Published on 03 Sep 2025

Inhibition of the oncogenic channel Kv10.1 by the antipsychotic drug penfluridol

in Pharmacology of Ion Channels and Channelopathies

Paulina León-Sánchez
Andrea Lizeth Cedillo-Hernández
María Luisa Durán-Pastén
Cesar Oliver Lara-Figueroa
Arturo Hernández-Cruz
Enoch Luis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655406

1,552 views

Original Research

Published on 02 Sep 2025

The interplay of polarizable water and protein in the activation of the M2 channel

in Pharmacology of Ion Channels and Channelopathies

Márta Gődény
Nóra Kovács
Aamir Aman
Thanyada Rungrotmongkol
Christian Schröder

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532697

1,254 views

Original Research

Published on 20 Aug 2025

CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis

in Pharmacology of Ion Channels and Channelopathies

Cláudia S. Rodrigues
Matilde Canto
Raquel Torres
Violeta Railean
Sofia S. Ramalho
Carlos M. Farinha
Ines Pankonien
Margarida D. Amaral

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655479

1,956 views

Original Research

Published on 04 Aug 2025

Selective amino acid formulation enhances anion secretion and restores function in cystic fibrosis mutations

in Pharmacology of Ion Channels and Channelopathies

Astrid Grosche
Anusree Sasidharan
Matthias Salathe
Nathalie Baumlin
Damiano Angoli
Sreekala Prabhakaran
Xiaodong Xu
Sadasivan Vidyasagar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522130

1,723 views

Review

Published on 29 Jul 2025

Factors that influence the Na/K-ATPase signaling and function

in Pharmacology of Ion Channels and Channelopathies

Yingnyu Gao
Yunhui Xu
Fang Bai
Raghav Puri
Jiang Tian
Jiang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639859

1,356 views

Review

Published on 04 Jun 2025

Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors

in Pharmacology of Ion Channels and Channelopathies

Jingxin Xin
Keling Yin
Shimeng Li
Peiyuan Gu
Shanshan Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580086

2,059 views

Original Research

Published on 21 May 2025

Loss of SynDIG4/PRRT1 alters distribution of AMPA receptors in Rab4- and Rab11-positive endosomes and impairs basal AMPA receptor recycling

in Pharmacology of Ion Channels and Channelopathies

Chun-Wei He
Elva Díaz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568908

1,180 views

Review

Published on 09 May 2025

The role of transient receptor potential channels in chronic kidney disease-mineral and bone disorder

in Pharmacology of Ion Channels and Channelopathies

Lerong Zhang
Penghao Xu
Lele Hao
Lingling Wang
Yunkai Xu
Chen Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583487

1,981 views

Review

Published on 30 Apr 2025

Inhibition of NMDA receptors and other ion channel types by membrane-associated drugs

in Pharmacology of Ion Channels and Channelopathies

Elizabeth G. Neureiter
M. Quincy Erickson-Oberg
Aparna Nigam
Jon W. Johnson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561956

2,610 views

Original Research

Published on 29 Apr 2025

Early reduction of skin potassium without sodium accumulation in the pathogenesis of salt sensitivity in primary aldosteronism

in Pharmacology of Ion Channels and Channelopathies

Petr Mlejnek
František Liška
Jan Šilhavý
Kateřina Večerková
Miroslava Šimáková
Michal Pravenec
Theodore W. Kurtz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575972

1,545 views

Original Research

Published on 22 Apr 2025

Gaussian white noise stimulation as an alternative method to excite sensory neurons

in Pharmacology of Ion Channels and Channelopathies

Thomas Losgott
Klaus W. Schicker
Karlheinz Hilber
Stefan Boehm
Isabella Salzer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561905

1,232 views

Original Research

Published on 10 Apr 2025

The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

in Pharmacology of Ion Channels and Channelopathies

Aurélie Antunes
Jérôme Montnach
Kuldip Khakh
Ludivine Lopez
Baptiste Thomas
Barbara Ribeiro Oliveira-Mendes
Lucie Jaquillard
Denis Servent
Rémy Béroud
Charles J. Cohen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566312

1,653 views
1 citation

Review

Published on 28 Mar 2025

Role of voltage-gated chloride channels in epilepsy: current insights and future directions

in Pharmacology of Ion Channels and Channelopathies

Ming-Ming Ni
Jie-Yu Sun
Zheng-Qian Li
Jin-Chun Qiu
Chun-Feng Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560392

1,742 views
1 citation

Review

Published on 26 Mar 2025

Sodium channels as a new target for pain treatment

in Pharmacology of Ion Channels and Channelopathies

Rui Chen
Yiran Liu
Liu Qian
Mingliang Yi
Hong Yin
Shun Wang
Bingbing Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573254

6,047 views
5 citations

Review

Published on 24 Mar 2025

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

in Pharmacology of Ion Channels and Channelopathies

Yuri M. Poluektov
Olga D. Lopina
Maria A. Strelkova
Iuliia D. Kuleshova
Alexander A. Makarov
Irina Yu. Petrushanko

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520927

1,511 views