Frontiers in Psychiatry | Molecular Psychiatry

Original Research

Published on 04 Sep 2025

Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia

in Molecular Psychiatry

Jiankang Lv
Xueru Wang
Wei Qin

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1621219

3,648 views

Review

Published on 02 Sep 2025

Neurobiological mechanisms of the effect of exercise on depressive disorder: analysis using CiteSpace

in Molecular Psychiatry

Haiying Yang
Jiayi Xu
Lei Hou
Dejian Huang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1600286

4,138 views

Original Research

Published on 12 Aug 2025

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

in Molecular Psychiatry

Wu Qianhao
Zhang Jinwen
Miao Jingjie
Chen Xiaoyu
Zhao Yangfei
Yao Wenxiu
Jiang Xu
Wang Xiaojun
Han Peipei
Guo Qi

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1627020

3,346 views
1 citation

Mini Review

Published on 23 Jul 2025

Beyond vertebrates: Drosophila melanogaster as a model to study negative symptoms of schizophrenia

in Molecular Psychiatry

Maximiliano Elgueta-Reyes
Sergio Hidalgo
Jorge M. Campusano

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1622281

4,082 views

Opinion

Published on 22 Jul 2025

CB1 receptor and psychosis: friend, foe, or both

in Molecular Psychiatry

Jagadeesh S. Rao
Maria Alejandra Tangarife
Diego A. Rodríguez-Soacha
Ram Mukunda

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1630080

2,194 views

Original Research

Published on 14 Jul 2025

Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder

in Molecular Psychiatry

Priyanka
Rajesh Kumar
Vinod Kumar
Ashwani Kumar
Sandeep Singh Rana

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1574458

4,872 views
2 citations

Original Research

Published on 01 Jul 2025

Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos

in Molecular Psychiatry

Wentian Li
Fang Wang
Zhe Feng
Qianqian Cheng
Yuqing Huang
Lisheng Zhu
Han Xiao
Hongjian Gong

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1581524

2,731 views

Original Research

Published on 27 Jun 2025

Psychiatric safety associated with hormone replacement therapy for menopausal symptoms: a real-world study of the FDA adverse event reporting system

in Molecular Psychiatry

Nan Chen
Lei Li
Chun-li Fu
Yi Ren

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1614087

5,564 views
1 citation

Original Research

Published on 27 Jun 2025

Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression

in Molecular Psychiatry

Jinli Gao
Qinglang Wang
Jie Liu
Siqian Zheng
Jiahong Liu
Zhiyong Gao
Cheng Zhu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1564095

2,243 views
1 citation

Editorial

Published on 04 Jun 2025

Editorial: Advances, opportunities and challenges of using modern AGI and AIGC technologies in depression and related disorders

in Molecular Psychiatry

Ming D. Li
Yunpeng Wang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1625579

3,383 views
2 citations

Original Research

Published on 20 May 2025

Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder

in Molecular Psychiatry

Xinyu Meng
Shengmin Zhang
Yingzhen Xu
Zaohui Ma
Shuzhe Zhou
Yantao Ma
Hong Ma
Xin Yu
Lili Guan

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1589374

2,013 views
1 citation

Original Research

Published on 14 May 2025

Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression

in Molecular Psychiatry

Hao Yu
Chengji Wang
Yao Wu
Changxing He
Shaohong Zou

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1574391

2,166 views

Original Research

Published on 12 May 2025

Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics

in Molecular Psychiatry

Mingxia Liu
Weigang Pan
Jing He
Sihai Ling
Yi He
Jian Yang
Peixian Mao
Zuoli Sun

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1558796

2,837 views

Systematic Review

Published on 29 Apr 2025

Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders

in Molecular Psychiatry

João Francisco Pollo Gaspary
Luis Felipe Dias Lopes
Antonio Geraldo Camara

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1537442

2,592 views
1 citation

Original Research

Published on 22 Apr 2025

Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders

in Molecular Psychiatry

Reon Kondo
Hiroki Kimura
Masashi Ikeda

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1566155

4,257 views
3 citations

Editorial

Published on 10 Apr 2025

Editorial: The individual and joint contributions of molecular and environmental factors on gene expression and psychopathology development

in Molecular Psychiatry

Gabriela Ariadna Martínez-Levy
Diego Luiz Rovaris
Rodrigo G. Arzate-Mejía
Jill A. Rabinowitz

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1599378

1,423 views

Original Research

Published on 21 Mar 2025

Sentence-level multi-modal feature learning for depression recognition

in Molecular Psychiatry

Guanghua Zhang
Guangping Zhuo
Yang Yang
Guohua Xu
Shukui Ma
Hao Liu
Zhiyong Ren

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1439577

3,006 views
2 citations

Review

Published on 18 Mar 2025

Knowledge graph and its application in the study of neurological and mental disorders

in Molecular Psychiatry

Qizheng Wang
Fan Yang
Lijie Quan
Mengjie Fu
Zhongli Yang
Ju Wang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1452557

5,769 views
1 citation

Original Research

Published on 12 Mar 2025

Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors

in Molecular Psychiatry

Jinni Su
Belal Jamil
Kit K. Elam
Angel D. Trevino
Kathryn Lemery-Chalfant
Eleanor K. Seaton
Rick A. Cruz
Kevin J. Grimm

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1505035

2,817 views
2 citations

Original Research

Published on 27 Feb 2025

LncRNA of peripheral blood mononuclear cells: HYMAI acts as a potential diagnostic and therapeutic biomarker for female major depressive disorder

in Molecular Psychiatry

Tianyi Bu
Jiarun Yang
Jiawei Zhou
Yeran Liu
Kexin Qiao
Yan Wang
Jili Zhang
Erying Zhao
Boakye Kwame Owura
Xiaohui Qiu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1241089

1,797 views

Original Research

Published on 20 Feb 2025

Proteome analysis of the prefrontal cortex and the application of machine learning models for the identification of potential biomarkers related to suicide

in Molecular Psychiatry

Manuel Alejandro Rojo-Romero
Nora Andrea Gutiérrez-Nájera
Carlos Sabás Cruz-Fuentes
Ana Luisa Romero-Pimentel
Roberto Mendoza-Morales
Fernando García-Dolores
Mirna Edith Morales-Marín
Xóchitl Castro-Martínez
Elier González-Sáenz
Jonatan Torres-Campuzano

Frontiers in Psychiatry

doi 10.3389/fpsyt.2024.1429953

4,704 views
1 citation

Original Research

Published on 18 Feb 2025

Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder

in Molecular Psychiatry

Xuan Wang
Di Cao
Hanlin Zhang
Wei Chen
Jiaxin Sun
Huimin Hu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1539596

3,379 views
6 citations

Original Research

Published on 14 Feb 2025

Assessing the feasibility of using salivary microRNAs as biomarkers to distinguish between chronic stress and childhood trauma in African American young women in an exploratory pilot study

in Molecular Psychiatry

Erica Holliday
Anisah Bagasra
Omar Bagasra
Pratima Pandey

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1507064

2,471 views
1 citation

Original Research

Published on 13 Feb 2025

Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study

in Molecular Psychiatry

Vanessa Kiyomi Ota
Adrielle Martins Oliveira
Amanda Victória Gomes Bugiga
Helena B. Conceição
Pedro Alexandre Favoretto Galante
Paula Fontes Asprino
Julia Luiza Schäfer
Mauricio Scopel Hoffmann
Rodrigo Bressan
Elisa Brietzke

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1505421

5,053 views
3 citations

534 articles

articles

Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia

Neurobiological mechanisms of the effect of exercise on depressive disorder: analysis using CiteSpace

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

Beyond vertebrates: Drosophila melanogaster as a model to study negative symptoms of schizophrenia

CB1 receptor and psychosis: friend, foe, or both

Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder

Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos

Psychiatric safety associated with hormone replacement therapy for menopausal symptoms: a real-world study of the FDA adverse event reporting system

Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression

Editorial: Advances, opportunities and challenges of using modern AGI and AIGC technologies in depression and related disorders

Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder

Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression

Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics

Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders

Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders

Editorial: The individual and joint contributions of molecular and environmental factors on gene expression and psychopathology development

Sentence-level multi-modal feature learning for depression recognition

Knowledge graph and its application in the study of neurological and mental disorders

Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors

LncRNA of peripheral blood mononuclear cells: HYMAI acts as a potential diagnostic and therapeutic biomarker for female major depressive disorder

Proteome analysis of the prefrontal cortex and the application of machine learning models for the identification of potential biomarkers related to suicide

Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder

Assessing the feasibility of using salivary microRNAs as biomarkers to distinguish between chronic stress and childhood trauma in African American young women in an exploratory pilot study

Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study