SYSTEMATIC REVIEW article
Front. Public Health
Sec. Injury Prevention and Control
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1573888
Global, regional, and national burden of fracture of vertebral column, 1990-2021: analysis of data from the global burden of disease study 2021
Provisionally accepted
- Guangxi Key Laboratory of Regenerative Medicine, Nanning, China
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Background: Fractures of the vertebral column, encompassing various spinal injuries, represent a significant public health burden worldwide. These injuries can lead to long-term disability, reduced quality of life, and substantial healthcare costs.We utilized comprehensive data sources from the Global Health Data Exchange (GHDx). The study employed the incidence, prevalence, and years lived with disability (YLDs) metric to quantify the burden. First, numbers and age-standardized rates (ASRs) of incidence, prevalence, and YLDs were assessed globally and by sub-types including sex, age, socio-demographic index (SDI) regions, 2 Global Burden of Disease Study (GBD) regions, and countries in 2021. Furthermore, the temporal trend of the disease burden was explored by the linear regression model from 1990 to 2021. The cluster analysis was used to evaluate the changing pattern of related disease burden across GBD regions. Finally, the age-period-cohort (APC) model were used to predict the future disease burden in the next 25 years.Results: Exposure to fracture of vertebral column contributed to 7497446 incidence, 5371438 prevalence, and 545923 YLDs globally in 2021. The disease burden was higher in males than in females. And it was higher in older adults. High SDI regions were high-risk areas. From 1990 to 2021, the number of cases showed the increasing trend, and the ASRs showed the decreasing trend. The predicted results showed that the number of cases for both genders would still increase from 2022 to 2046.Our findings highlight the substantial and growing global burden of vertebral column fractures, with significant variations across regions and countries.Targeted interventions to address modifiable risk factors, such as osteoporosis and falls, are essential to mitigate the burden.
Keywords: fracture of vertebral column, Global burden of disease, Incidence, Prevalence, Years lived with disability
Received: 10 Feb 2025; Accepted: 08 Apr 2025.
Copyright: © 2025 Lan, Chen, Lan, Li and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiyong Wei, Guangxi Key Laboratory of Regenerative Medicine, Nanning, China
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