Frontiers in Toxicology

Original Research

Accepted on 26 Aug 2025

Daflon and Centrum Mitigate Vancomycin-Induced Nephrotoxicity in Rats by Ameliorating Oxidative Stress, DNA Damage, Apoptosis, and Inflammation

Hanem F El-Gendy
Soaad Salamah
Eman Elhusseiny
Hazim Khalifa
Hossny Elbanna
Taha A Attia
Shaimaa Selim
Saber El Hanbally

Frontiers in Toxicology

doi 10.3389/ftox.2025.1673083

Original Research

Accepted on 25 Aug 2025

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

José Manuel Horcas-Nieto
Sabine Hartvelt
Luke Flatt
Jing Fang
Esther Lam
Gaonan Zhang
Romy van Vliet
Marleen Feliksik
Tom Zwetsloot
Connor Philippo

Frontiers in Toxicology

doi 10.3389/ftox.2025.1645842

Systematic Review

Published on 25 Aug 2025

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Jorge Vasconez-Gonzalez
Juan S. Izquierdo-Condoy
Karen Delgado-Moreira
María de Lourdes Noboa-Lasso
Esteban Gamez-Rivera
Camila Salazar-Santoliva
María Belén Lopez-Molina
Esteban Ortiz-Prado

Frontiers in Toxicology

doi 10.3389/ftox.2025.1632308

585 views

Hypothesis and Theory

Published on 21 Aug 2025

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

Melissa Badding
Noor Aly
Kevin Sondenheimer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1639737

353 views

Original Research

Published on 21 Aug 2025

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Brigitta R. Szabo
Jeroen Stein
Anna Savchenko
Thomas Hutschalik
Filip Van Nieuwerburgh
Tim Meese
Georgios Kosmidis
Paul G. A. Volders
Elena Matsa

Frontiers in Toxicology

doi 10.3389/ftox.2025.1644119

434 views

Original Research

Published on 18 Aug 2025

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

Liliana Zúñiga-Venegas
Natalia Landeros
Floria Pancetti
Sandra Cortés
Boris Lucero
Ana M. Brito
Ian S. Acuña-Rodríguez
María Teresa Muñoz-Quezada

Frontiers in Toxicology

doi 10.3389/ftox.2025.1588408

695 views

Original Research

Accepted on 11 Aug 2025

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

Rob Stierum
Manosij Ghosh
Marjolein Meijerink
Xavier Pinho
Vivi Schlunssen
Anjoeka Pronk
Jolanda Van Bilsen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589380

182 views

Perspective

Published on 11 Aug 2025

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Riccardo Leinardi
François Huaux

Frontiers in Toxicology

doi 10.3389/ftox.2025.1625874

482 views

Original Research

Published on 11 Aug 2025

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Alvaro-Flavio Marinas-Lacasta
Ian M. Fearon
Matthew Stevenson
Tasnim Abusalem
Fiona Chapman
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Ole Dethloff
Ourania Komini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589480

1,445 views

Original Research

Accepted on 08 Aug 2025

Reproduction of the Human Relevant Potency Threshold (HRPT) for Estrogen Receptor Alpha Agonism in an Inference Performance Screen for ICCVAM's Regulatory Scientific Confidence Framework

Jessica Ryman Ph.D., D.A.B.T.
Richard Becker

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657708

498 views

Review

Published on 08 Aug 2025

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

Tilo Weber
Atena Malakpour-Permlid
Aline Chary
Vito D’Alessandro
Leah Haut
Sebastian Seufert
Esther Veronika Wenzel
James Hickman
Karen Bieback
Joachim Wiest

Frontiers in Toxicology

doi 10.3389/ftox.2025.1612903

2,396 views

Original Research

Accepted on 07 Aug 2025

Error-Corrected Next Generation Sequencing Mutagenicity Assays in Human HepaRG™ Cells as Human-Relevant Genetic Toxicology New Approach Methodology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657189

263 views

Original Research

Published on 06 Aug 2025

Epidemiological investigation of venomous snakebites in Yunnan Province

Qinfen Gao
Yajun Teng
Chao Xiao
Rui Zeng
Bin Han
Hong Gao
Jianhai Wang
Xiaoyan Li
Canju Yang
Jianneng Dai

Frontiers in Toxicology

doi 10.3389/ftox.2025.1609487

1,035 views

Case Report

Accepted on 04 Aug 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration, a case report and literature review

Isidora Semnic
Valentino Racki
Vladimira Vuletić

Frontiers in Toxicology

doi 10.3389/ftox.2025.1580275

245 views

Original Research

Accepted on 04 Aug 2025

Exploring Plasticisers-Osteoporosis Links and Mechanisms: A Cohort and Network Toxicology Study

Xingyao Yang
Xin Wang
Shifu Bao
Zhengjiang Li
Shuxing Xing
Zhangzhen Du

Frontiers in Toxicology

doi 10.3389/ftox.2025.1617663

120 views

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

757 views

542 Publications

Volume 7 - 2025

Daflon and Centrum Mitigate Vancomycin-Induced Nephrotoxicity in Rats by Ameliorating Oxidative Stress, DNA Damage, Apoptosis, and Inflammation

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers

Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Reproduction of the Human Relevant Potency Threshold (HRPT) for Estrogen Receptor Alpha Agonism in an Inference Performance Screen for ICCVAM's Regulatory Scientific Confidence Framework

Fetal bovine serum: how to leave it behind in the pursuit of more reliable science

Error-Corrected Next Generation Sequencing Mutagenicity Assays in Human HepaRG™ Cells as Human-Relevant Genetic Toxicology New Approach Methodology

Epidemiological investigation of venomous snakebites in Yunnan Province

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration, a case report and literature review

Exploring Plasticisers-Osteoporosis Links and Mechanisms: A Cohort and Network Toxicology Study

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies